EXTL3 Antikörper (AA 351-450) (HRP)

Produktnummer ABIN1711956

Dieses Anti-EXTL3-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von EXTL3 in WB, ELISA, IHC (p) und IHC (fro). Geeignet für Ratte.

Kurzübersicht für EXTL3 Antikörper (AA 351-450) (HRP) (ABIN1711956)

Target: EXTL3 (Exostoses (Multiple)-Like 3 (EXTL3))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EXTL3 Antikörper ist konjugiert mit HRP

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-EXTL3 Antikörper (HRP)

Bindungsspezifität: AA 351-450

Kreuzreaktivität: Ratte

Homologie: Human,Mouse,Dog,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human EXTL3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handhabung: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu EXTL3

Target: EXTL3 (Exostoses (Multiple)-Like 3 (EXTL3))

Andere Bezeichnung: EXTL3

Hintergrund:

Synonyms: botv, DKFZp686C2342, Exostoses multiple-like 3, Exostoses-like 3, Exostosin-like 3, EXT-related protein 1, EXTL1L, EXTL3, EXTL3_HUMAN, EXTR1, Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferas, Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase, Hereditary multiple exostoses gene isolog, KIAA0519, Multiple exostosis-like protein 3, Putative tumor suppressor protein EXTL3, REG, Reg receptor, REGR, RPR.

Background: EXTL3 is a member of the EXT (hereditary multiple exostosin) gene family of tumor suppressors encoding glycosyltransferases involved in heparan sulfate (HS) biosynthesis. Within this family, the C-terminus is conserved between all members from C. elegans to vertebrates. EXTL3 is a ubiquitously expressed, developmentally regulated, single-pass type II membrane protein that localizes to the endoplasmic reticulum membrane. EXTL3 adds N-acetylglucosamine (GlcNAc) to the polysaccharide-protein linkage region and to the growing HS chain suggesting that it plays a role in both the initiation and elongation of HS chains. In addition, EXTL3 may act as a Reg receptor, binding Reg via its N-terminus.

Gen-ID: 2137

Pathways: Glycosaminoglycan Metabolic Process, ER-Nucleus Signaling