GAS2 Antikörper (AA 141-240) (HRP)

Produktnummer ABIN1711320

Dieses Anti-GAS2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von GAS2 in ELISA, IHC (fro) und IHC (p). Geeignet für Human.

Kurzübersicht für GAS2 Antikörper (AA 141-240) (HRP) (ABIN1711320)

Target: GAS2 (Growth Arrest-Specific 2 (GAS2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GAS2 Antikörper ist konjugiert mit HRP

Applikation: ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-GAS2 Antikörper (HRP)

Bindungsspezifität: AA 141-240

Homologie: Human,Mouse,Rat,Cow,Sheep,Pig

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GAS2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handhabung: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu GAS2

Target: GAS2 (Growth Arrest-Specific 2 (GAS2))

Andere Bezeichnung: GAS2

Hintergrund:

Synonyms: GAS 2, GAS-2, Gas2, GAS2_HUMAN, Growth arrest specic 2, Growth arrest specic protein 2, Growth arrest-specic protein 2, MGC32610.

Background: Gas2 is a 313 amino acid protein encoded by the human gene GAS2. Gas2 is thought to play a role in apoptosis by acting as a cell death substrate for caspases. Gas2, a component of the microfilament system, is cleaved by a caspase (caspase-3 and caspase-7) at Asparagine 278 during apoptosis. The cleaved form resulting from this dramatically induces the rearrangement of the Actin cytoskeleton and causes potent changes in the shape of the affected cells. Gas2 is believed to also be involved in the membrane ruffling process. During the G0-G1 transition phase Gas2 can be found phosphorylated on its serine residues. Gas2 is a cytoskeleton and peripheral membrane protein that co-localizes with Actin fibers at the cell border and along the stress fibers in growth-arrested fibroblasts. Gas2 is mainly membrane-associated but when hyperphosphorylated it will accumulate at membrane ruffles. Gas2 is specifically expressed at growth arrest and is ubiquitously expressed with highest levels found in liver, lung and kidney. There is no evidence, however, of Gas2 expression in spleen.

Gen-ID: 2620

Pathways: Caspase Kaskade in der Apoptose