GADL1 Antikörper (AA 51-150) (HRP)

Produktnummer ABIN1711316

Der Kaninchen Polyklonal Anti-GADL1-Antikörper wurde für ELISA, IHC (fro) und IHC (p) validiert. Er ist geeignet, GADL1 in Proben von Human zu detektieren.

Kurzübersicht für GADL1 Antikörper (AA 51-150) (HRP) (ABIN1711316)

Target: GADL1 (Glutamate Decarboxylase-Like 1 (GADL1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GADL1 Antikörper ist konjugiert mit HRP

Applikation: ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-GADL1 Antikörper (HRP)

Bindungsspezifität: AA 51-150

Homologie: Human,Mouse,Rat,Bee

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GADL1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handhabung: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu GADL1

Target: GADL1 (Glutamate Decarboxylase-Like 1 (GADL1))

Andere Bezeichnung: GADL1

Hintergrund:

Synonyms: GADL1, GADL1_HUMAN, Glutamate decarboxylase like 1, Glutamate decarboxylase-like protein 1, MGC138191, OTTHUMP00000161199, OTTHUMP00000222306.

Background: There are two forms of glutamic acid decarboxylases (GADs) that exist in brain: GAD-65 (also known as GAD2) and GAD-67 (also known as GAD1, GAD or SCP). GAD-65 and GAD-67 are members of the group II decarboxylase family of proteins and are responsible for catalyzing the rate limiting step in the production of GABA (gamma-aminobutyric acid) from L-glutamic acid. Although both GADs are found in brain, GAD-65 localizes to synaptic vesicle membranes in nerve terminals, while GAD-67 is distributed throughout the cell. GAD-67 is responsible for the basal levels of GABA synthesis. In the case of a heightened demand for GABA in neurotransmission, GAD-65 transiently activates to assist in GABA production. As a member of the group II decarboxylase family, GADL1 (Glutamate decarboxylase-like protein 1) is a 521 amino acid protein that utilizes pyridoxal phosphate as a cofactor for its carboxylase activity. There are two isoforms of GADL1 that exist as a result of alternative splicing events.

Gen-ID: 339896