DTX2 Antikörper (AA 331-430) (HRP)

Produktnummer ABIN1711284

Dieses Anti-DTX2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von DTX2 in WB, ELISA, IHC (p) und IHC (fro). Geeignet für Human.

Kurzübersicht für DTX2 Antikörper (AA 331-430) (HRP) (ABIN1711284)

Target: DTX2 (Deltex Homolog 2 (DTX2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DTX2 Antikörper ist konjugiert mit HRP

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-DTX2 Antikörper (HRP)

Bindungsspezifität: AA 331-430

Homologie: Human,Mouse,Rat,Horse,Zebrafish

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human DTX2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handhabung: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu DTX2

Target: DTX2 (Deltex Homolog 2 (DTX2))

Andere Bezeichnung: DTX2

Hintergrund:

Synonyms: Deltex 2, Deltex2, hDTX2, Highly similar to hPMSR6 [H.sapiens], Protein deltex 2, RING finger protein 58, RNF58, Zinc ion binding protein, DTX2_HUMAN.

Background: DTX2 belongs to the Deltex family. It contains one RING-type zinc finger and two WWE domains. DTX2 is a regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. It probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context, mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. DTX2 also functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases. There are two named isoforms.

Gen-ID: 113878

Pathways: Notch Signalweg