CMKLR1 Antikörper (AA 171-280) (HRP)

Produktnummer ABIN1711154

Der Kaninchen Polyklonal Anti-CMKLR1-Antikörper wurde für WB, ELISA, IHC (p) und IHC (fro) validiert. Er ist geeignet, CMKLR1 in Proben von Human und Maus zu detektieren.

Kurzübersicht für CMKLR1 Antikörper (AA 171-280) (HRP) (ABIN1711154)

Target: CMKLR1 (Chemokine-Like Receptor 1 (CMKLR1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CMKLR1 Antikörper ist konjugiert mit HRP

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-CMKLR1 Antikörper (HRP)

Bindungsspezifität: AA 171-280

Kreuzreaktivität: Human, Maus

Homologie: Dog,Sheep

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CMKLR1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu CMKLR1

Target: CMKLR1 (Chemokine-Like Receptor 1 (CMKLR1))

Andere Bezeichnung: CMKLR1

Hintergrund:

Synonyms: Chemokine receptor-like 1, CHEMR23, ChemR23, DEZ, Chemokine like receptor 1, G protein coupled receptor ChemR23, G protein coupled receptor DEZ, CML1_HUMAN , Orphan G protein coupled receptor.

Background: Chemokine-Like Receptor 1 (CMKLR1) is a serpentine transmembrane G-protein linked receptor. It is an orphan chemoattractant receptor, also known as ChemR23 or DEZ. CMKLR1 is expressed on the surface of monocyte-derived immature dendritic cells and peripheral plamacytoid dendritic (pDC) cells, but not on myeloid dendritic (mDC) cells, monocytes and lymphocytes. The expression of CMKLR1 on pDC is down-regulated after activation. Chemerin (TIG2) is a natural ligand of CMKLR1. The interaction of CMKLR1 with Chemerin induces pDC activation and chemotaxis. It has been shown that CMKLR1 is a coreceptor for several strains of SIV and HIV-1. CMKLR1 is a potential useful marker for distinguishing pDCs and mDCs.

Gen-ID: 1240