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GAB4 Antikörper (AA 101-200) (Cy7)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch GAB4 in WB, IF (cc) und IF (p). Er zeigt eine Reaktivität gegenüber Human.
Produktnummer ABIN1708678

Kurzübersicht für GAB4 Antikörper (AA 101-200) (Cy7) (ABIN1708678)

Target

GAB4 (GRB2-Associated Binding Protein Family, Member 4 (GAB4))

Reaktivität

Human

Wirt

  • 27
Kaninchen

Klonalität

  • 27
Polyklonal

Konjugat

  • 9
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser GAB4 Antikörper ist konjugiert mit Cy7

Applikation

  • 26
  • 12
  • 12
  • 11
  • 10
  • 3
  • 3
  • 1
  • 1
  • 1
Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • Bindungsspezifität

    • 14
    • 8
    • 3
    • 2
    • 1
    • 1
    • 1
    AA 101-200

    Homologie

    Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human GAB4

    Isotyp

    IgG
  • Applikationshinweise

    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Haltbarkeit

    12 months
  • Target

    GAB4 (GRB2-Associated Binding Protein Family, Member 4 (GAB4))

    Andere Bezeichnung

    GAB4

    Hintergrund

    Synonyms: GAB2-like, GAB4, GAB4_HUMAN, GRB2 associated binder 2 like protein, GRB2 associated binding protein family member 4, GRB2-associated binder 2-like, GRB2-associated binder 4, GRB2-associated-binding protein 2-like, GRB2-associated-binding protein 4, Growth factor receptor bound protein 2-associated protein 4.

    Background: The Gab family of adaptor proteins function as molecular scaffolds that mediate protein recruit-ment to RTKs. Cytokine/growth factor triggering of protein tyrosine kinase receptors (RTKs) initiates signaling cascades that progress to the nucleus where signals for activation, proliferation and differentiation occur. This scaffolding mechanism represents a critical link in cytokine/growth factor signaling routes. Gab 1-4 contain Pleckstrin homology and potential binding sites for SH2 and SH3 domain-containing proteins. The recruitment of signaling partners to Gab family members is phosphorylation-dependent. Insulin receptor and EGF receptor signaling are among the cascades that rely on Gab family members to elicit a nuclear response to an extracellular stimulus. Gab 4 (GRB2-associated-binding protein 4), also designated GRB2-associated-binding protein 2-like (Gab 2-like), is a 574 amino acid protein that shares 62 % sequence similarity with Gab 2 and contains one Pleckstrin homology domain.

    Gen-ID

    128954
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