Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.
Synonyms: Adenylate cyclase inhibiting G alpha protein, Adenylate cyclase inhibitory protein, Adenylate cyclase-inhibiting G alpha protein, G protein alpha inhibiting 1, G protein alpha inhibiting activity polypeptide 1, Gi, Gi inhibitory G protein, Gi1 protein alpha subunit, GNAI 1, GNAI1, GNAI1_HUMAN, Guanine nucleotide binding protein G protein alpha inhibiting activity polypeptide 1, Guanine nucleotide binding protein alpha inhibiting activity polypeptide 1, Guanine nucleotide binding protein Gi alpha 1 subunit, Guanine nucleotide-binding protein Gi subunit alpha-1, OTTHUMP00000161319, OTTHUMP00000208047.