CRYAB Antikörper (Crystallin, alpha B) (pSer59) (Cy5)

Details for Product anti-CRYAB Antibody No. ABIN1705043
Antigen
  • CMD1II
  • CRYA2
  • CTPP2
  • CTRCT16
  • HSPB5
  • MFM2
  • Crya-2
  • Crya2
  • HspB5
  • AACRYA
  • CRYAB
  • cryab
  • crystallin alpha B
  • crystallin, alpha B
  • hypothetical protein
  • crystallin, alpha B, a
  • CRYAB
  • Cryab
  • ZK1128.7
  • cryaba
Epitop
pSer59
39
39
34
29
21
15
13
12
10
9
9
7
4
4
3
3
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
536
325
267
196
56
50
12
10
6
6
4
4
3
Wirt
Kaninchen
303
224
17
1
Klonalität
Polyklonal
Konjugat
Dieser CRYAB Antikörper ist konjugiert mit Cy5
23
19
18
11
11
11
9
9
9
9
9
8
8
8
8
8
8
8
8
8
8
8
6
6
6
6
6
6
5
3
3
3
3
3
2
2
2
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
424
262
246
113
96
80
77
57
29
19
5
2
2
Optionen
Immunogen KLH conjugated synthetic phosphopeptide derived from human alpha B Crystallin around the phosphorylation site of Ser59
Isotyp IgG
Reinigung Purified by Protein A.
Plasmids, Primers & others Plasmide, Primers & weitere CRYAB products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung alpha B Crystallin (CRYAB Antibody Abstract)
Hintergrund

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families, beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone, instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits, the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B gene products are differentially expressed, alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases, a missense mutation cosegregated in a family with a desmin-related myopathy. [provided by RefSeq, Jul 2008].

Synonyms: alpha B Crystallin phospho S59, alpha B Crystallin phospho Ser59, p-alpha B Crystallin S59, p-alpha B Crystallin Ser59, AACRYA, Alpha B crystallin, Alpha crystallin B chain, Alpha crystallin B chain, AlphaB crystallin, AlphaB-crystallin, Alpha-crystallin B chain, CRYA2, CRYAB, CRYAB_HUMAN, Crystallin alpha B, Crystallin alpha polypeptide 2, CTPP 2, CTPP2, Heat shock 20 kD like protein, Heat shock protein beta 5, Heat shock protein beta-5, HSPB5, NY REN 27 antigen, Renal carcinoma antigen NY REN 27, Renal carcinoma antigen NY-REN-27, Rosenthal fiber component.

Gen-ID 1410
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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