This gene belongs to the GPI family whose members encode multifunctional phosphoglucose isomerase proteins involved in energy pathways. The protein encoded by this gene is a dimeric enzyme that catalyzes the reversible isomerization of glucose-6-phosphate and fructose-6-phosphate. The protein functions in different capacities inside and outside the cell. In the cytoplasm, the gene product is involved in glycolysis and gluconeogenesis, while outside the cell it functions as a neurotrophic factor for spinal and sensory neurons. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. [provided by RefSeq, Jul 2008].
Synonyms: Glucose 6 phosphate isomerase, AMF, Aurocrine motility factor, Autocrine motility factor, DKFZp686C13233, EC 126.96.36.199, G6PI_HUMAN, Glucose phosphate isomerase, Glucose-6-phosphate isomerase, GNPI, GPI, Gpi1, Hexose monophosphate isomerase, Hexosephosphate isomerase, Neuroleukin, NLK, Oxoisomerase, PHI, Phosphoglucose isomerase, Phosphohexomutase, Phosphohexose isomerase, Phosphosaccharomutase, SA 36, SA-36, SA36, Sperm antigen 36.