GLTSCR2 Antikörper (Glioma Tumor Suppressor Candidate Region Gene 2) (Cy5)

Details for Product anti-GLTSCR2 Antibody No. ABIN1704931
Antigen
  • GLTSCR2
  • pict1
  • pict-1
  • MGC115044
  • PICT-1
  • PICT1
  • 5330430H08Rik
  • 9430097C02Rik
  • AU041936
  • AW536441
  • R74911
  • NOP53 ribosome biogenesis factor
  • NOP53 ribosome biogenesis factor L homeolog
  • Nop53
  • NOP53
  • nop53
  • nop53.L
Reaktivität
Human, Maus, Ratte (Rattus)
54
17
17
3
3
2
1
Wirt
Kaninchen
33
14
8
Klonalität
Polyklonal
Konjugat
Dieser GLTSCR2 Antikörper ist konjugiert mit Cy5
4
4
4
3
3
3
1
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
32
30
12
7
3
Optionen
Immunogen KLH conjugated synthetic peptide derived from human GLTSCR2/PICT1
Isotyp IgG
Reinigung Purified by Protein A.
Plasmids, Primers & others Plasmide, Primers & weitere GLTSCR2 products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung Gltscr2/Pict1
Hintergrund

The tumor suppressor PTEN plays an essential role in regulating signaling pathways involved in cell growth and apoptosis and is inactivated in a wide variety of tumors. Protein interacting with PTEN carboxyl terminus 1 (PICT-1), also designated p60 or Glioma tumor suppressor candidate region gene 2 protein, binds to the C-terminus of PTEN and regulates its turnover. Five Ser/Thr residues within the C-terminal segment of PTEN, including Ser-380, are phosphorylated upon binding of PTEN to PICT-1 and may contribute to the stabilization of PTEN. PICT-1 is localized to the nucleus and/or nucleolus and is highly expressed in pancreas and heart, but can also be detected in liver, skeletal muscle, placenta and kidney. PICT-1 also interacts with herpes simplex virus 1 regulatory proteins ICP22 and ICP0. The tumor suppressor GLTSCR2 gene, which encodes PICT-1, is located in a 150-kb minimal common deletion region for human gliomas, especially oligodendrogliomas, and maps to human chromosome 19q13.3.

Synonyms: Glioma tumor suppressor candidate region gene 2 protein, GLTSCR2, GSCR2_HUMAN, p60, PICT1, protein interacting with carboxyl terminus 1.

Gen-ID 29997
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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