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GLTSCR2 Antikörper (AA 401-478) (Cy5)

GLTSCR2 Reaktivität: Maus WB, IF (p), IF (cc) Wirt: Kaninchen Polyclonal Cy5
Produktnummer ABIN1704931
  • Target Alle GLTSCR2 Produkte
    GLTSCR2 (Glioma Tumor Suppressor Candidate Region Gene 2 (GLTSCR2))
    Bindungsspezifität
    • 14
    • 8
    • 7
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 401-478
    Reaktivität
    • 21
    • 14
    • 1
    • 1
    Maus
    Wirt
    • 29
    • 5
    • 1
    Kaninchen
    Klonalität
    • 33
    • 2
    Polyklonal
    Konjugat
    • 12
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser GLTSCR2 Antikörper ist konjugiert mit Cy5
    Applikation
    • 34
    • 19
    • 12
    • 12
    • 4
    • 3
    • 3
    • 1
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))
    Kreuzreaktivität
    Maus
    Homologie
    Human,Rat,Dog,Cow,Sheep,Pig,Horse
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human GLTSCR2/PICT1
    Isotyp
    IgG
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    GLTSCR2 (Glioma Tumor Suppressor Candidate Region Gene 2 (GLTSCR2))
    Andere Bezeichnung
    GLTSCR2/PICT1 (GLTSCR2 Produkte)
    Synonyme
    GLTSCR2 antikoerper, pict1 antikoerper, pict-1 antikoerper, MGC115044 antikoerper, PICT-1 antikoerper, PICT1 antikoerper, 5330430H08Rik antikoerper, 9430097C02Rik antikoerper, AU041936 antikoerper, AW536441 antikoerper, R74911 antikoerper, NOP53 ribosome biogenesis factor antikoerper, NOP53 ribosome biogenesis factor L homeolog antikoerper, Nop53 antikoerper, NOP53 antikoerper, nop53 antikoerper, nop53.L antikoerper
    Hintergrund

    Synonyms: Glioma tumor suppressor candidate region gene 2 protein, GLTSCR2, GSCR2_HUMAN, p60, PICT1, protein interacting with carboxyl terminus 1.

    Background: The tumor suppressor PTEN plays an essential role in regulating signaling pathways involved in cell growth and apoptosis and is inactivated in a wide variety of tumors. Protein interacting with PTEN carboxyl terminus 1 (PICT-1), also designated p60 or Glioma tumor suppressor candidate region gene 2 protein, binds to the C-terminus of PTEN and regulates its turnover. Five Ser/Thr residues within the C-terminal segment of PTEN, including Ser-380, are phosphorylated upon binding of PTEN to PICT-1 and may contribute to the stabilization of PTEN. PICT-1 is localized to the nucleus and/or nucleolus and is highly expressed in pancreas and heart, but can also be detected in liver, skeletal muscle, placenta and kidney. PICT-1 also interacts with herpes simplex virus 1 regulatory proteins ICP22 and ICP0. The tumor suppressor GLTSCR2 gene, which encodes PICT-1, is located in a 150-kb minimal common deletion region for human gliomas, especially oligodendrogliomas, and maps to human chromosome 19q13.3.

    Gen-ID
    29997
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