GHRHR Antikörper (Growth Hormone Releasing Hormone Receptor) (Cy5)

Details for Product anti-GHRHR Antibody No. ABIN1704925
Antigen
  • GHRFR
  • GRFR
  • IGHD1B
  • Ghrfr
  • lit
  • little
  • GHRHREC
  • GHRH-R
  • growth hormone releasing hormone receptor
  • GHRHR
  • Ghrhr
Reaktivität
Human, Maus, Ratte (Rattus)
88
55
54
6
6
5
5
5
4
4
4
Wirt
Kaninchen
88
Klonalität
Polyklonal
Konjugat
Dieser GHRHR Antikörper ist konjugiert mit Cy5
3
3
3
2
2
2
2
2
2
2
2
2
2
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
46
25
21
19
15
11
5
4
1
1
1
Optionen
Immunogen KLH conjugated synthetic peptide derived from human GHRHR
Isotyp IgG
Reinigung Purified by Protein A.
Plasmids, Primers & others Plasmide, Primers & weitere GHRHR products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung GHRHR (GHRHR Antibody Abstract)
Hintergrund

GHRH-R is a seven transmembrane domain protein that localizes to the somatotroph of the pituitary. GHRH-R plays an important role in growth and acts as a high-affinity receptor for GHRH. Binding of GHRH leads to the coupling of GHRH-R to G-protein which stimulates increased adenylyl cyclase activity and the accumulation of cAMP leading to the synthesis and release of growth hormone and somatotroph proliferation. In addition, this signalling pathway may have direct action in fetal/placental development, reproduction and immune function. GHRH and GHRH-R may also play a role in the regulation of non-rapid eye movement sleep (NREMS). The expression of GHRH-R is dependent on the presence of the POU domain factor Pit-1. Mutations in the gene encoding this protein can result in isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, and anterior pituitary hypoplasia (APH).

Synonyms: GHRFR, GHRH R, GHRH receptor, Ghrhr, GHRHR_HUMAN, GHRHRpsv, GRF R, GRF receptor, GRFR, Growth hormone releasing factor receptor, Growth hormone releasing hormone receptor, Growth hormone-releasing factor receptor, Growth hormone-releasing hormone receptor.

Gen-ID 2692
Pathways Intracellular Steroid Hormone Receptor Signaling Pathway, Hormone Transport, Regulation of Intracellular Steroid Hormone Receptor Signaling, cAMP Metabolic Process
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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