GGA1 Antikörper (Golgi-Associated, gamma Adaptin Ear Containing, ARF Binding Protein 1) (Cy5)

Details for Product anti-GGA1 Antibody No. ABIN1704922
Antigen
  • 4930406E12Rik
  • AU016030
  • AW209092
  • fb33h10
  • im:6912200
  • wu:fb33h10
  • zgc:101044
  • putative golgi associated, gamma adaptin ear containing,arf binding protein 1 (gga1)
  • golgi associated, gamma adaptin ear containing, ARF binding protein 1
  • golgi-associated, gamma adaptin ear containing, ARF binding protein 1
  • Smp_164030
  • Gga1
  • gga1
  • GGA1
Reaktivität
Human, Maus, Ratte (Rattus)
65
34
21
3
2
2
1
1
1
1
1
Wirt
Kaninchen
58
8
Klonalität
Polyklonal
Konjugat
Dieser GGA1 Antikörper ist konjugiert mit Cy5
4
4
4
2
2
2
1
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
49
31
17
12
7
6
6
3
2
2
1
Optionen
Immunogen KLH conjugated synthetic peptide derived from human GGA1
Isotyp IgG
Reinigung Purified by Protein A.
Plasmids, Primers & others Plasmide, Primers & weitere GGA1 products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung Gga1 (GGA1 Antibody Abstract)
Hintergrund

The GGA family of proteins (Golgi-localized, ARF-binding proteins) are ubiquitous coat proteins that facilitate the trafficking of soluble proteins from the trans-Golgi network (TGN) to endosomes/lysosomes by means of interactions with TGN-sorting receptors, ARF (ADP-ribosylation factor), and clathrin (1?). Members of the GGA family, GGA1,GGA2 (also known as VEAR) and GGA3, are multidomain proteins that bind mannose 6-phosphate receptors (MPRs) (1,2,4). GGAs have modular structures with an N-terminal VHS (VPS-27, Hrs, and STAM) domain followed by a GAT (GGA and TOM1) domain, a connecting hinge segment, and a C-terminal GAE (?adaptin ear) domain (5). The amino-terminal VHS domains of GGAs form complexes with the cytoplasmic domains of sorting receptors by recognizing acidic-cluster di-leucine (ACLL) sequences (3). GGA1 and GGA2 do not associate with each other, but they do colocalize on perinuclear membranes (2). The cytosolic domain of memapsin 2, but not that of memapsin 1, binds the VHS domains of GGA1 and GGA2 (6). The human GGA1 gene maps to chromosome 22 and encodes a protein that shares 45 % sequence identity with GGA2 and GGA3 (1).

Synonyms: 4930406E12Rik, ADP ribosylation factor binding protein 1, ADP ribosylation factor binding protein GGA1, ADP-ribosylation factor-binding protein GGA1, ARF binding protein 1, ARF-binding protein 1, Gamma adaptin related protein 1, gamma ear-containing, Gamma-adaptin-related protein 1, GGA 1, GGA1, GGA1 protein, GGA1_HUMAN, Golgi associated gamma adaptin ear containing ARF, Golgi associated gamma adaptin ear containing ARF binding protein 1, Golgi localized gamma ear containing ARF binding protein 1, Golgi-localized, OTTHUMP00000028975, OTTHUMP00000042200.

Gen-ID 26088
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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