EYA4 Antikörper (Eyes Absent Homolog 4 (Drosophila)) (Cy5)

Details for Product anti-EYA4 Antibody No. ABIN1704870
Antigen
  • B130023L16Rik
  • CMD1J
  • DFNA10
  • EYA transcriptional coactivator and phosphatase 4
  • Eya4
  • EYA4
Reaktivität
Human, Maus, Ratte (Rattus)
71
21
17
6
5
3
2
2
2
2
Wirt
Kaninchen
55
17
Klonalität
Polyklonal
Konjugat
Dieser EYA4 Antikörper ist konjugiert mit Cy5
5
5
5
3
3
3
1
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
38
36
28
21
13
12
3
2
2
1
Optionen
Immunogen KLH conjugated synthetic peptide derived from human EYA4
Isotyp IgG
Reinigung Purified by Protein A.
Plasmids, Primers & others Plasmide, Primers & weitere EYA4 products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung Eya4 (EYA4 Antibody Abstract)
Hintergrund

A gene of chromosome 6q23 encodes the 640 amino acid protein, EYA4 (eyes absent) (1). EYA is one of four members of the eyes absent family (1). A 271 amino acid domain at the carboxyl terminal is highly conserved amongst the members of the eyes absent family (1). EYA4 is expressed in the craniofacial mesenchyme, the dermamyotome, and the limb (1). The conserved region in other EYA proteins interacts with SIX, DACH, and G-proteins, which regulate transcription in early embryonic development (1,2,3,4). SIX translocates EYA1-3 to the nucleus, and G-proteins can stop this interaction (3,4). Premature stop codon mutations in EYA4 cause postlingual, progressive autosomal dominant hearing loss in humans (2). This shows that EYA4 is also vital to the mature organ of Corti (2). EYA4 may cause oculo-dento-digital syndrome, based on its expression pattern and map postion (1).

Synonyms: CMD1J, Deafness, autosomal dominant 10, DFNA 10, DFNA10, dJ78N10.1 eyes absent Drosophila homolog 4, dJ78N10.1 eyes absent, EYA 4, eya4, EYA4_HUMAN, Eyes absent 4, Eyes absent homolog 4 Drosophila, Eyes absent homolog 4, HGNC:3522, OTTHUMP00000040267.

Gen-ID 2070
Pathways Sensory Perception of Sound
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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