Exosome Component 10 (EXOSC10) Antikörper (Cy5)

Details zu Produkt Nr. ABIN1704867
Antigen
  • Pmscl2
  • zgc:55695
  • pm-scl
  • pm/scl-100
  • pmscl
  • pmscl2
  • rrp6
  • rrp6p
  • EXOSC10
  • 201.t00018
  • 21.m02990
  • DDBDRAFT_0203581
  • DDBDRAFT_0233752
  • DDB_0203581
  • DDB_0233752
  • PM-Scl
  • PM/Scl-100
  • PMSCL
  • PMSCL2
  • RRP6
  • Rrp6p
  • p2
  • p3
  • p4
  • exosome component 10
  • 3'-5' exonuclease
  • exosome component 10 L homeolog
  • exosc10
  • EXOSC10
  • EHI_021400
  • BBOV_IV002650
  • CpipJ_CPIJ003896
  • CMU_031760
  • Tsp_05247
  • exosc10.L
  • Exosc10
Reaktivität
Human, Maus, Ratte (Rattus)
40
23
19
6
6
5
3
2
1
1
Wirt
Kaninchen
37
3
Klonalität
Polyklonal
Konjugat
Cy5
2
2
2
1
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
20
15
14
12
6
4
2
2
Optionen
Immunogen KLH conjugated synthetic peptide derived from human EXOSC10/PMSCL2
Isotyp IgG
Reinigung Purified by Protein A.
Antigen
Andere Bezeichnung Exosc10/Pmscl2 (EXOSC10 Antibody Abstract)
Hintergrund

The exosome is a multi-subunit complex composed of several highly conserved proteins, some of which are 3’ to 5’ exoribonucleases. The complex is involved in a variety of cellular processes and is responsible for degrading unstable mRNAs that contain AU-rich (ARE) elements in their untranslated 3’ region. EXOSC10, also known as PMSCL, PMSCL2, p2, p3, p4, RRP6, Rrp6p, PM-Scl, or PM/Scl-100, is an 885 amino acid protein that contains one HRDC domain and one 3’-5’ enonuclease domain. Localized to both the cytoplasm and the nucleus, EXOSC10 is part of the post-splicing exosome complex and is involved in mRNA surveillance, mRNA nuclear export and nonsense-mediated decay of mRNAs containing premature stop codons. against EXOSC10 have been found in patients with scleroderma and/or polymyositis (chronic diseases of the skin and muscle, respectively), suggesting that EXOSC10 may be involved in the pathogenesis of these diseases. Two isoforms of EXOSC10 exist due to alternative splicing events.

Synonyms: Autoantigen PM/Scl 2, Exosc10, Exosome component 10, EXOSX_HUMAN, P100 polymyositis scleroderma overlap syndrome associated autoantigen, P100 polymyositis-scleroderma overlap syndrome-associated autoantigen, p2, p3, p4, PM Scl, PM/Scl 100, PM/Scl-100, PMSCL, PMSCL2, Polymyositis/scleroderma autoantigen 100 kDa, Polymyositis/scleroderma autoantigen 2 100 kDa, Polymyositis/scleroderma autoantigen 2, RRP6, Rrp6p.

Gen-ID 5394
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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