Solute Carrier Family 1 (High Affinity Aspartate/glutamate Transporter), Member 6 (SLC1A6) Antikörper (Cy5)

Details zu Produkt Nr. ABIN1704855
Antigen
  • SLC1A6
  • zgc:171923
  • EAAT4
  • solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
  • solute carrier family 1 member 6
  • excitatory amino acid transporter 4-like
  • SLC1A6
  • slc1a6
  • LOC100224299
  • Slc1a6
Reaktivität
Human, Maus, Ratte (Rattus)
56
39
35
2
2
1
1
1
1
1
1
Wirt
Kaninchen
54
6
Klonalität
Polyklonal
Konjugat
Cy5
3
2
2
2
2
2
2
2
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
38
22
12
10
4
3
2
2
2
1
Optionen
Immunogen KLH conjugated synthetic peptide derived from human EAAT4
Isotyp IgG
Reinigung Purified by Protein A.
Antigen
Andere Bezeichnung Eaat4 (SLC1A6 Antibody Abstract)
Hintergrund

Excitatory Amino Acid Transporters (EAATs) are membrane-bound proteins that are localized in glial cells and pre-synaptic glutamatergic nerve endings. EAATs transport the excitatory neurotransmitters L-glutamate and D-aspartate, a process that is essential for terminating the postsynaptic action of glutamate. The re-uptake of amino acid neurotransmitters by EAAT proteins has been shown to protect neurons from excitotoxicity, which is caused by the accumulation of amino acid neurotransmitters. EAAT4 is an aspartate/glutamate transporter that is expressed predominantly in the cerebellum. The transport activity encoded by EAAT4 has high apparent affinity for L-aspartate and L-glutamate, and has a pharmacologic profile consistent with previously described cerebellar transport activities. EAAT5 is a glutamate transporter coupled to a chloride conductance which is expressed primarily in retina. Although EAAT5 shares the structural homologies of the EAAT family, a novel feature of the EAAT5 sequence is a carboxy-terminal motif previously identified in N-ethyl-D-aspartate receptors and potassium channels and shown to confer interactions with a family of synaptic proteins that promote ion channel clustering.

Subcellular location: Extracellular

Synonyms: Excitatory amino acid transporter 4, High affinity neuronal glutamate transporter, MGC33092, MGC43671, Sodium dependent glutamate/aspartate transporter, Solute carrier family 1 high affinity aspartate/glutamate transporter member 6, Solute carrier family 1 member 6,

Gen-ID 6511
Pathways Dicarboxylic Acid Transport
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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