Bloom Syndrome RecQ Like Helicase (BLM) Antikörper (Cy5)

Details zu Produkt Nr. ABIN1704789
Antigen
  • BS
  • RECQ2
  • RECQL2
  • RECQL3
  • blm-A
  • xBLM
  • ORF1
  • Bloom syndrome RecQ like helicase
  • Bloom syndrome RecQ like helicase S homeolog
  • Bloom syndrome, RecQ like helicase
  • BLM
  • blm.S
  • Blm
Reaktivität
Human, Maus, Ratte (Rattus)
102
19
16
1
1
1
1
1
Wirt
Kaninchen
85
11
8
Klonalität
Polyklonal
Konjugat
Cy5
5
5
5
3
3
3
2
2
2
2
2
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
70
57
19
16
15
14
12
6
3
2
2
1
Optionen
Immunogen KLH conjugated synthetic peptide derived from human BLM/Blooms Syndrome Protein Blm
Isotyp IgG
Reinigung Purified by Protein A.
Antigen
Hintergrund

Bloom’s syndrome is an autosomal recessive disorder characterized by pre- and post-natal growth deficiencies, sun sensitivity, immunodeficiency and a predisposition to various cancers. The gene responsible for Bloom’s syndrome, BLM, encodes a protein homologous to the RecQ helicase of E. coli and is mutated in most Bloom’s syndrome patients. One characteristic of Bloom’s syndrome is an increased frequency of sister chromatid exchange (SCE). BLM has been shown to unwind G4 DNA, and a failure of this function is thought to be responsible for the increased rate of SCE. BLM is known to be translocated to the nucleus, where its ATPase activity is stimulated by both single- and double-stranded DNA. Mutations in the yeast SGS1, a homolog of BLM, are known to cause mitotic hyperrecombination similiar to that observed in Bloom’s cells.

Synonyms: BLM, BLM_HUMAN, Bloom Syndrome, Bloom syndrome protein, Bloom syndrome RecQ helicase like, BS, DNA Helicase, DNA helicase RecQ like type 2, MGC126616, MGC131618, MGC131620, RECQ 2, RECQ like, RecQ like type 2, RecQ protein like 3, RecQ Protein-like 3, RECQ-2, RECQ-Like, RecQ-like type 2, RECQ2, RECQL 2, RECQL 3, RECQL-2, RECQL-3, RECQL2, RECQL3, type 2.

Gen-ID 641
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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