Eukaryotic gene transcription is regulated by sequence-specific transcription factors that bind modular cis acting promoter and enhancer elements. The ATF/CREB transcription factor family binds the palindromic cAMP response element (CRE) octanucleotide TGACGTCA. The best characterized members of this gene family include CREB-1, CREB-2 (also designated ATF-4), CRE-BPa, LZIP (also designated CREB3 and Luman), CREM-1, CREM-2, ATF-1, ATF-2, ATF-3, ATF-5, ATF-6 and ATF-7. This family of proteins contain highly divergent N-terminal domains, but share a C-terminal leucine zipper for dimerization and DNA binding. ATF-5 (ATFx), which can localize to the cytoplasm or the nucleus, binds DNA as a dimer. It interacts with CCND3 and PTP4A1.
Synonyms: Activating transcription factor 5 alpha/beta, Activating transcription factor 5, Activating transcription factor X, AFTA, ATF 5, ATF 7, ATF7, ATFX, BZIP protein ATF7, cAMP dependent transcription factor ATF 5, cAMP dependent transcription factor ATF5, Cyclic AMP dependent transcription factor ATF 5, Cyclic AMP dependent transcription factor ATF5, FLJ34666, HMFN0395, MGC102397, NAP1, NR3 associated protein, ODA 10, Transcription factor ATFx, Transcription factor like protein ODA 10, Transcription factor like protein ODA10, ATF5_HUMAN.