Argininosuccinate Lyase (ASL) Antikörper (Cy5)

Details zu Produkt Nr. ABIN1704717
Antigen
  • ASAL
  • 2510006M18Rik
  • zgc:63532
  • BA4879
  • PSPTO0125
  • argininosuccinate lyase
  • argininosuccinate lyase ArgH
  • argininosuccinate lyase L homeolog
  • ASL
  • Asl
  • asl
  • argH2
  • argH
  • arg7
  • CNC04420
  • STHERM_c13370
  • asl.L
  • ARG7
Reaktivität
Human, Maus, Ratte (Rattus)
77
39
29
6
6
6
6
6
5
4
3
3
3
3
3
3
2
Wirt
Kaninchen
67
10
Klonalität
Polyklonal
Konjugat
Cy5
4
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
42
16
13
12
11
9
7
4
4
2
2
2
1
Optionen
Immunogen KLH conjugated synthetic peptide derived from human ASL/Argininosuccinate Lyase
Isotyp IgG
Reinigung Purified by Protein A.
Antigen
Andere Bezeichnung Asl/Argininosuccinate Lyase (ASL Antibody Abstract)
Hintergrund

ASL is a member of the lyase 1 family of proteins and is predominantly expressed in the liver. Localizing to the cytoplasm and existing as a homotetramer, ASL catalyzes the hydrolytic cleavage of argininosuccinic acid (ASA) to fumarate and arginine, an essential step of the urea cycle which is crucial for the detoxification of ammonia. This reaction is also involved in the biosynthesis of arginine. In addition, ASL shares high sequence homology with the avian and reptilian eye lens protein, d-crystallin. Mutations in the gene encoding ASL leads to an accumulation of ASA in body fluids and results in Arginosuc-cinic aciduria (ASAuria), an autosomal recessive disorder that is characterized by hyperammonemia, liver enlargement, convulsions, physical and mental retardation, episodic unconsciousness and dry and brittle hair showing trich-orrhexis nodosa (weak points or nodes in the hair shaft).

Synonyms: Argininosuccinase, Argininosuccinate lyase, Arginosuccinase, ARLY_HUMAN, ASAL, ASL, EC 4.3.2.1.

Gen-ID 435
Pathways Response to Growth Hormone Stimulus
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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