Anaphase Promoting Complex Subunit 11 (ANAPC11) Antikörper (Cy5)

Details zu Produkt Nr. ABIN1704710
Antigen
  • APC11
  • Apc11p
  • anapc11
  • RGD1561880
  • DDBDRAFT_0187183
  • DDBDRAFT_0231277
  • DDB_0187183
  • DDB_0231277
  • 1110011I19Rik
  • R75218
  • zgc:153671
  • si:dkey-237i9.4
  • anaphase promoting complex subunit 11
  • anaphase promoting complex subunit 11 L homeolog
  • anaphase-promoting complex subunit Apc11
  • ubiquitin-protein ligase Anaphase Promoting Complex
  • hypothetical protein
  • predicted protein
  • anaphase-promoting complex subunit 11
  • APC11 anaphase promoting complex subunit 11 homolog (yeast)
  • ANAPC11
  • anapc11.L
  • anapc11
  • Anapc11
  • APC11
  • apc11
  • CAALFM_CR10610CA
  • LOC9320604
  • LOC692923
Reaktivität
Human, Maus, Ratte (Rattus)
76
27
24
Wirt
Kaninchen
37
31
11
Klonalität
Polyklonal
Konjugat
Cy5
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
60
38
23
12
12
10
6
4
3
2
2
1
Optionen
Immunogen KLH conjugated synthetic peptide derived from human APC11
Isotyp IgG
Reinigung Purified by Protein A.
Antigen
Andere Bezeichnung Apc11 (ANAPC11 Antibody Abstract)
Hintergrund

Comprising more than ten subunits, the anaphase-promoting complex (APC) acts in a cell-cycle dependent manner to promote the separation of sister chromatids during the transition between metaphase and anaphase in mitosis. APC, or cyclosome, accomplishes this progression through the ubiquitination of mitotic cyclins and other regulatory proteins that are targeted for destruction during cell division. APC is phosphorylated, and thus activated, by protein kinases Cdk1/cyclin B and polo-like kinase (Plk). APC is under tight control by a number of regulatory factors, including CDC20, CDH1 and MAD2. Specifically, CDC20 and CDH1 directly bind to APC and activates APC’s cyclin-ubiquitination activity. In contrast, MAD2 inhibits APC by forming a ternary complex with CDC20 and APC, thus preventing APC activation. APC11 is a RING-H2 finger protein that allows for the synthesis of multiubiquitin chains in the presence of Ubiquitin carrier protein 4 (Ubc4) and ubiquitin conjugating enzyme (E2). In addition, a heterodimeric complex of either Ubc4 or UbcH10 with APC11 and APC2 catalyzes the ubiquitination of human securin and cyclin B1.

Synonyms: ANAPC 11, ANAPC11, Anaphase promoting complex subunit 11, Anaphase promoting complex subunit 11 homolog yeast, Anaphase promoting complex subunit 11 homolog, Anaphase-promoting complex subunit 11, Apc 11, Apc 11p, APC11 anaphase promoting complex subunit 11 homolog yeast, APC11 anaphase promoting complex subunit 11 homolog, APC11, APC11_HUMAN, Apc11p, Cyclosome subunit 11, Hepatocellular carcinoma associated RING finger protein, Hepatocellular carcinoma-associated RING finger protein, HSPC 214, HSPC214, MGC882, Yeast APC 11 homolog, Yeast APC11 homolog.

Gen-ID 51529
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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