Guanylate Cyclase Activator 1A (Retina) (GUCA1A) Antikörper (Cy5)

Details zu Produkt Nr. ABIN1704665
Antigen
  • C6orf131
  • COD3
  • CORD14
  • GCAP
  • GCAP1
  • GUCA
  • GUCA1
  • dJ139D8.6
  • MGC84170
  • GUCA1A
  • guca1a
  • MGC146317
  • GC-A
  • Gcap1
  • Guca1
  • mGCAP1
  • gcap1
  • guanylate cyclase activator 1A
  • guanylate cyclase activator 1A L homeolog
  • guanylate cyclase activator 1A (retina)
  • guanylate cyclase activator 1a (retina)
  • GUCA1A
  • Guca1a
  • guca1a.L
  • guca1a
Reaktivität
Human, Maus, Ratte (Rattus)
59
23
23
2
2
1
1
1
1
1
1
Wirt
Kaninchen
54
5
Klonalität
Polyklonal
Konjugat
Cy5
4
4
4
2
2
2
1
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
41
32
18
12
8
2
1
Optionen
Immunogen KLH conjugated synthetic peptide derived from human GCAP1
Isotyp IgG
Reinigung Purified by Protein A.
Antigen
Andere Bezeichnung Gcap1 (GUCA1A Antibody Abstract)
Hintergrund

intracellular stimulation of guanylate cyclase (GC) by calcium, a key event in the recovery of the dark state of rod photoreceptors after exposure to light, is mediated by guanylate cyclase-activating protein (GCAP1). GCAPs are calcium-The binding proteins belonging to the calmodulin superfamily. GCAP1 is a calcium-binding protein that stimulates synthesis of c-GMP in photoreceptors. GCAP1 is present in rod and cone photoreceptor outer segments where phototransduction occurs. In contrast to other calcium-binding proteins from the calmodulin superfamily, the calcium-free form of GCAP1 stimulates the effector enzyme. By molecular cloning of human and mouse GCAP cDNA, the known mammalian GCAPs are found to be more than 90 % similar, consisting of 201 to 205 amino acids, and containing three identically conserved calcium-binding sites. A related protein, GCAP2, is detectable only in the retina and results from a gene duplication event.

Synonyms: COD3, GCAP 1, GCAP, Guanylate Cyclase Activating Protein Photoreceptor 1, Guanylate Cyclase Activating Protein Photoreceptor 1, Guanylate Cyclase Activator 1A, Guanylate Cyclase Activator 1A, Guanylin 1, Guanylin 1, guanylyl cyclase activating protein 1, Guanylyl cyclase-activating protein 1, GUC1A_HUMAN, GUCA, GUCA1, GUCA1A, GUCA1A.

Gen-ID 2978
Pathways Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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