Destrin Antikörper (Destrin (Actin Depolymerizing Factor)) (Cy5)

Details for Product anti-DSTN Antibody No. ABIN1704639
Antigen
  • ACTDP
  • ADF
  • bA462D18.2
  • DSTN
  • LOC100190417
  • adf
  • actdp
  • ba462d18.2
  • 2610043P17Rik
  • AU042046
  • Dsn
  • corn1
  • sid23p
  • destrin
  • destrin, actin depolymerizing factor
  • destrin
  • destrin, actin depolymerizing factor S homeolog
  • DSTN
  • dstn
  • Dstn
  • dstn.S
Reaktivität
Human, Maus, Ratte (Rattus)
92
26
24
13
10
2
2
2
2
1
1
1
1
1
Wirt
Kaninchen
65
27
Klonalität
Polyklonal
Konjugat
Dieser Destrin Antikörper ist konjugiert mit Cy5
5
4
4
2
2
2
2
2
2
2
2
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
66
47
41
27
14
12
11
2
2
1
1
Optionen
Immunogen KLH conjugated synthetic peptide derived from human Destrin
Isotyp IgG
Reinigung Purified by Protein A.
Plasmids, Primers & others Plasmide, Primers & weitere Destrin products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung Destrin (DSTN Antibody Abstract)
Hintergrund

Actin-depolymerizing factor (ADF), also known as destrin, is a member of the ADF/Cofilin/destrin superfamily that has the ability to rapidly depolymerize F-Actin in a stoichiometric manner. The Actin-depolymerizing activity of ADF is reversibly controlled by changes in KCl concentration but is insensitive to calcium concentration. ADF depolymerizes F-Actin by interacting directly with F-Actin protomers. ADF shares 71 % sequence homology with Cofilin, however the two proteins differ in their interaction with Actin. The difference in the function of ADF and Cofilin results from the subtle difference in their amino acid sequence rather than possible differences in posttranslational modifications. As a result of different cleavage sites on ADF and Cofilin, the proteins differ in their overall tertiary folds. Sensitivity to polyphosphoinositides may be a common feature in vitro among Actin-binding proteins such as ADF and Cofilin that can bind to G-Actin and regulate the state of Actin polymerization. ADF and Cofilin are Actin-depolymerizing proteins whose activities are possibly regulated by their phosphorylation/dephosphorylation.

Synonyms: 2610043P17Rik, ACTDP, Actin depolymerizing factor, Actin-depolymerizing factor, ADF, AU042046, bA462D18.2, corn1, DEST_HUMAN, Destrin actin depolymerizing factor, Destrin, DSN, Dstn, Sid 23, sid23p.

Gen-ID 11034
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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