Fanconi Anemia, Complementation Group C (FANCC) Antikörper (Cy5)

Details zu Produkt Nr. ABIN1704563
Antigen
  • zgc:154105
  • FANCC
  • fa3
  • fac
  • facc
  • FA3
  • FAC
  • FACC
  • BB116513
  • Facc
  • Fanconi anemia complementation group C
  • Fanconi anemia, complementation group C
  • Fanconi anemia complementation group C L homeolog
  • FANCC
  • fancc
  • fancc.L
  • Fancc
Reaktivität
Human, Maus, Ratte (Rattus)
117
27
18
2
2
Wirt
Kaninchen
102
16
Klonalität
Polyklonal
Konjugat
Cy5
6
5
4
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
95
47
42
38
23
18
13
12
7
6
4
2
1
Optionen
Immunogen KLH conjugated synthetic peptide derived from human FANCC
Isotyp IgG
Reinigung Purified by Protein A.
Antigen
Andere Bezeichnung Fancc (FANCC Antibody Abstract)
Hintergrund

Fanconi anemia (FA) is an autosomal recessive disorder characterized by bone marrow failure, birth defects and chromsomal instability (1,2). The FA Group C complementation group gene encodes the protein FANCC, which is located in both cytoplasmic and nuclear compartments. FANCC is expressed in a cell cycle-dependent manner, with the lowest levels at the G1/S boundary and the highest levels in the M-phase. The FANCC protein interacts with other FA complementation group proteins as well as non-FA proteins (3). A human a spectrin II (designated aSpIIs) acts as a scaffold to enhance interactions between FANCC and FANCA to form a nuclear complex (4,5). Another binding partner of FANCC is the BTB/POZ domain containing protein FAZF, which is a transcriptional repressor (6). In hematopoietic cells expressing mutant FANCC, PKR is constitutively phosphorylated and has increased binding affinity for double-stranded RNA (7,8), which suggests that FANCC indirectly suppresses the activity of PKR. These cells are also apoptotic and are hypersensitive to IFNg and TNFa (8). In addition, FANCC protein is involved in the activation of STAT1 through receptors for at least three hematopoietic growth and survival factors (8).

Synonyms: bA80I15.1, FA 3, FA3, FAC, FACC, FANCC, FANCC_HUMAN, Fanconi anemia complementation group C, Fanconi anemia complementation group C protein, Fanconi anemia group C protein, Fanconi pancytopenia type 3, FLJ14675, Protein FACC.

Gen-ID 2176
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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