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EXTL3 Antikörper (AA 351-450) (Cy5)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch EXTL3 in WB, IF (cc) und IF (p). Er zeigt eine Reaktivität gegenüber Ratte.
Produktnummer ABIN1704562

Kurzübersicht für EXTL3 Antikörper (AA 351-450) (Cy5) (ABIN1704562)

Target

Alle EXTL3 Antikörper anzeigen
EXTL3 (Exostoses (Multiple)-Like 3 (EXTL3))

Reaktivität

  • 41
  • 15
  • 10
  • 1
Ratte

Wirt

  • 55
Kaninchen

Klonalität

  • 54
Polyklonal

Konjugat

  • 20
  • 5
  • 5
  • 4
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser EXTL3 Antikörper ist konjugiert mit Cy5

Applikation

  • 44
  • 27
  • 23
  • 12
  • 12
  • 9
  • 7
  • 3
  • 2
  • 1
  • 1
Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • Bindungsspezifität

    • 14
    • 6
    • 6
    • 5
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 351-450

    Kreuzreaktivität

    Ratte

    Homologie

    Human,Mouse,Dog,Horse

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human EXTL3

    Isotyp

    IgG
  • Applikationshinweise

    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Haltbarkeit

    12 months
  • Target

    EXTL3 (Exostoses (Multiple)-Like 3 (EXTL3))

    Andere Bezeichnung

    EXTL3

    Hintergrund

    Synonyms: botv, DKFZp686C2342, Exostoses multiple-like 3, Exostoses-like 3, Exostosin-like 3, EXT-related protein 1, EXTL1L, EXTL3, EXTL3_HUMAN, EXTR1, Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferas, Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase, Hereditary multiple exostoses gene isolog, KIAA0519, Multiple exostosis-like protein 3, Putative tumor suppressor protein EXTL3, REG, Reg receptor, REGR, RPR.

    Background: EXTL3 is a member of the EXT (hereditary multiple exostosin) gene family of tumor suppressors encoding glycosyltransferases involved in heparan sulfate (HS) biosynthesis. Within this family, the C-terminus is conserved between all members from C. elegans to vertebrates. EXTL3 is a ubiquitously expressed, developmentally regulated, single-pass type II membrane protein that localizes to the endoplasmic reticulum membrane. EXTL3 adds N-acetylglucosamine (GlcNAc) to the polysaccharide-protein linkage region and to the growing HS chain suggesting that it plays a role in both the initiation and elongation of HS chains. In addition, EXTL3 may act as a Reg receptor, binding Reg via its N-terminus.

    Gen-ID

    2137

    Pathways

    Glycosaminoglycan Metabolic Process, ER-Nucleus Signaling
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