ARID3B represents a member of a unique family of DNA-binding proteins that have roles in cell lineage gene regulation, cell cycle control, embryonic patterning and transcriptional regulation. ARID3B localizes to the nucleus and contains an AT-rich interactive domain (ARID) which has DNA-binding capabilities. Functioning as a transcription factor, ARID3B associates in a heterodimer with the related protein ARID3A and is believed to play an important role in neural crest survival during embryogenesis. In addition, ARID3B may participate in malignant transformation and neuroblastoma growth, suggesting a possible use of ARID3B as a tumor marker for neuroblastoma.
Synonyms: ARI3B_HUMAN, ARID domain containing protein 3B, ARID domain-containing protein 3B, Arid3b, AT rich interactive domain 3B BRIGHT like, AT rich interactive domain containing protein 3B, AT-rich interactive domain-containing protein 3B, Bright and dead ringer gene product homologous protein Bdp, Bright and dead ringer protein, Bright like, Bright-like protein, Brightlike, DRIL2.