VAV3 Antikörper (Vav 3 Oncogene) (pTyr141) (Cy5)

Details for Product anti-VAV3 Antibody No. ABIN1704532
Antigen
  • RGD1565941
  • A530094I06Rik
  • AA986410
  • Idd18.1
  • vav guanine nucleotide exchange factor 3
  • vav 3 guanine nucleotide exchange factor
  • vav 3 oncogene
  • VAV3
  • Vav3
Epitop
pTyr141
23
15
14
8
5
4
4
3
2
2
2
1
1
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
110
57
30
2
2
Wirt
Kaninchen
91
21
Klonalität
Polyklonal
Konjugat
Dieser VAV3 Antikörper ist konjugiert mit Cy5
7
5
4
4
4
4
4
4
3
2
2
2
2
2
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
71
39
25
15
11
5
3
2
1
1
Optionen
Immunogen KLH conjugated synthetic phosphopeptide derived from human VAV3 around the phosphorylation site of Tyr141
Isotyp IgG
Reinigung Purified by Protein A.
Plasmids, Primers & others Plasmide, Primers & weitere VAV3 products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung VAV3 (VAV3 Antibody Abstract)
Hintergrund

The Vav family of Rho guanine nucleotide exchange factors (GEFs) orchestrate signaling events following lymphocyte antigen receptor activation. Vav3, like Vav (also known as Vav1 or p95Vav), undergoes tyrosine phosphorylation downstream of T cell receptor cross-linkage, and subsequently interacts with 2 adaptor molecules, SLP76 and 3BP2. Following these events, however, the paths of Vav and Vav3 diverge, Vav affects IL-2 promotor activity, while Vav3 impacts gene transcription linked to serum response element (SRE). Furthermore, Vav3 expression follows a cell cycle-dependent pattern, with transient upregulation occuring during mitosis. Encforced Vav3 expression leads to the appearance of multinucleate cells, implicating a role for Vav3 in the control of cytokinesis.

Subcellular location: Cytoplasm

Synonyms: VAV3phospho Y141, Guanine nucleotide exchange factor VAV3, Protein vav 3, Protein vav3, VAV 3, Vav 3 guanine nucleotide exchange factor, VAV 3 oncogene, VAV 3 protein, VAV-3, Vav3, VAV3 oncogene, VAV3 protein, VAV3_HUMAN.

Gen-ID 10451
Pathways Fc-epsilon Rezeptor Signalübertragung, Neurotrophin Signalübertragung
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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