Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. This gene is a member of the junctophilin gene family. Alternative splicing has been observed at this locus and two variants encoding distinct isoforms are described. [provided by RefSeq, Jul 2008].
Subcellular location: Cytoplasm
Synonyms: FLJ40969, JP-2, JP2, JPH2, JPH2_HUMAN, Junctophilin 2, Junctophilin type 2, Junctophilin-2, OTTHUMP00000031651, OTTHUMP00000031652.