CSK Antikörper (C-Src tyrosine Kinase) (pSer364) (Cy5)

Details for Product anti-CSK Antibody No. ABIN1704453
Antigen
  • AW212630
  • C-terminal Src kinase
  • c-src tyrosine kinase
  • CSK, non-receptor tyrosine kinase
  • CSK
  • Csk
Epitop
pSer364
33
30
14
11
9
9
9
7
5
4
3
3
3
3
3
2
2
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
209
125
106
12
9
6
5
4
2
2
2
2
1
Wirt
Kaninchen
156
33
23
Klonalität
Polyklonal
Konjugat
Dieser CSK Antikörper ist konjugiert mit Cy5
11
7
7
5
5
5
5
5
5
5
5
4
2
2
2
2
2
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
163
90
42
25
22
20
16
11
8
7
2
1
1
Optionen
Immunogen KLH conjugated synthetic phosphopeptide derived from human CSK around the phosphorylation site of Ser364
Isotyp IgG
Reinigung Purified by Protein A.
Plasmids, Primers & others Plasmide, Primers & weitere CSK products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung Csk (CSK Antibody Abstract)
Hintergrund

All members of the Src gene family of tyrosine kinases are characterized by a carboxy terminal domain tyrosine which is highly phosphorylated in the inactive form of the enzyme and phosphorylated to a much lesser extent when the enzyme is active. In the case of Src p60, Y527 is this tyrosine, however, a mutant form of c-Src in which Y527 is replaced by phenylalanine is transforming and displays 5- to 10-fold elevated kinase activity compared to its normal counterpart. Csk has been identified as a Src-related tyrosine kinase having both SH2 and SH3 domains and a catalytic domain but lacking sequences amino terminal to the SH3 domain as well as carboxy terminal regulatory sequences. Csk phosphorylates Src on Y527 and also downregulates Lyn, Fyn and Lck by tyrosine phosphorylation of carboxy terminal regulatory sites.

Synonyms: CSKphospho S364, p-CSKphospho S364, C SRC, C SRC kinase, C src Tyrosine Kinase, C-SRC kinase, c-src tyrosine kinase, Csk A, CSK, CSK_HUMAN, CYTOPLASMIC TYROSINE KINASE, EC 2.7.10.2, MGC112926, MGC117393, MGC154049, P60 Src, Protein tyrosine kinase CYL, Protein-tyrosine kinase CYL, Proto oncogene tyrosine protein kinase, Tyrosine protein kinase CSK, Tyrosine-protein kinase CSK, zgc:154049.

Gen-ID 1445
Pathways T-Zell Rezeptor Signalweg, EGFR Signaling Pathway, Cell-Cell Junction Organization, CXCR4-mediated Signaling Events
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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