This gene encodes a subunit of the elongation factor-1complex, which is responsible for the enzymatic delivery ofaminoacyl tRNAs to the ribosome. This subunit, delta, functions asguanine nucleotide exchange factor. It is reported that followingHIV-1 infection, this subunit interacts with HIV-1 Tat. Thisinteraction results in repression of translation of host cellproteins and enhanced translation of viral proteins. Severalalternatively spliced transcript variants encoding multipleisoforms have been found for this gene. Related pseudogenes havebeen defined on chromosomes 1, 6, 7, 9, 11, 13, 17, 19.[provided byRefSeq, Aug 2010].
Synonyms: Antigen NY CO 4, Antigen NY-CO-4, EEF 1D, EEF1D, EF 1 delta, EF 1D, EF-1-delta, EF1D, EF1D_HUMAN, Elongation factor 1 delta, Elongation factor 1-delta, Eukaryotic translation elongation factor 1 delta, Guanine nucleotide exchange protein.