Ataxin 1 Antikörper (ATXN1) (pSer775) (Cy5)

Details for Product anti-ATXN1 Antibody No. ABIN1704367
Antigen
  • ATX1
  • D6S504E
  • SCA1
  • ATXN1
  • ataxin 1b
  • atxn1
  • 2900016G23Rik
  • Atx1
  • C85907
  • ENSMUSG00000074917
  • Gm10786
  • Sca1
  • CG4547
  • Dmel\\CG4547
  • dAtx-1
  • dAtx1
  • sca1
  • ataxin 1
  • ataxin 1b
  • Ataxin 1
  • ATXN1
  • atxn1b
  • Atxn1
  • Atx-1
Epitop
pSer775
77
76
33
16
16
8
5
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
270
252
175
5
4
3
2
2
2
2
1
1
1
1
Wirt
Kaninchen
177
133
9
3
Klonalität
Polyklonal
Konjugat
Dieser Ataxin 1 Antikörper ist konjugiert mit Cy5
17
13
11
11
11
10
9
9
8
8
8
8
8
8
8
8
5
5
5
5
5
4
4
2
2
2
2
2
2
2
2
2
2
2
2
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
250
118
96
91
86
78
48
25
21
13
3
2
2
Optionen
Immunogen KLH conjugated synthetic phosphopeptide derived from human Ataxin 1 around the phosphorylation site of Ser776
Isotyp IgG
Reinigung Purified by Protein A.
Plasmids, Primers & others Plasmide, Primers & weitere Ataxin 1 products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung Ataxin 1 (ATXN1 Antibody Abstract)
Hintergrund

Ataxin-1, also designated spinocerebellar ataxia type 1 protein (Sca-1), is differentially expressed and localizes to both the cytoplasm and the nucleus. Mutations in Ataxin-1 are associated with the onset of the autosomal dominant neurodegenerative disorder spinocerebellar ataxia type 1 (SCA-1), which is characterized by progressive neuronal loss in the cerebellum, muscle wasting and ataxia. In Purkinje cells, where SCA-1 is predominantly observed, Ataxin-1 has been shown to directly associate with the Purkinje-enriched leucine-rich acidic nuclear protein (LANP) and the nuclear matrix-associated protein promyelocytic leukemia protein PML. In SCA-1, Ataxin-1 is mutated to encode a polyglutamine protein that forms nuclear aggregates, which interact significantly more strongly with LANP and contribute to the pathogenesis of SCA-1.

Synonyms: Ataxin 1 phospho S776,p-Ataxin 1 phospho S776, ATX1, ATXN1, SCA1, Ataxin 1, Ataxin-1, Ataxin1, Spinocerebellar ataxia type 1, ATX1_HUMAN.
Gen-ID 6310
Pathways Synaptic Membrane
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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