Mig-2 recruits migfilin to cell-matrix adhesions, while the interaction with filamin mediates the association of migfilin with actin filaments. Together, Mig-2, migfilin and filamin define a connection between cell matrix adhesions and the actin cytoskeleton and participate in the orchestration of actin assembly and cell shape modulation. Mig-2 expression is transcriptionally elevated in leiomyomas and could be involved in its hormone-mediated growth of leiomyomas of the uterus. Expression of Mig-2 is ubiquitous, and it is found in numerous tumor tissues.
Synonyms: FLJ34213, FLJ44462, UNC112, FERM2_HUMAN, Fermitin family homolog 2, Fermt2, KIND2, Kindlin-2, MIG-2, MIG2, Mitogen-inducible gene 2 protein, PH domain-containing family C member 1, Pleckstrin homology domain containing family C with FERM domain member 1, Pleckstrin homology domain-containing family C member 1, PLEKHC1, UNC112B.