Hook Homolog 1 (Drosophila) (HOOK1) Antikörper (Cy5)

Details zu Produkt Nr. ABIN1704320
Antigen
  • si:dkey-183n20.14
  • A930033L17Rik
  • azh
  • HK1
  • HOOK1
  • hook microtubule tethering protein 1
  • hook microtubule-tethering protein 1
  • HOOK1
  • hook1
  • Hook1
Reaktivität
Human, Maus, Ratte (Rattus)
63
26
23
2
1
1
1
1
1
1
Wirt
Kaninchen
57
6
Klonalität
Polyklonal
Konjugat
Cy5
4
4
4
2
2
2
1
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
49
29
12
12
5
3
1
1
Optionen
Immunogen KLH conjugated synthetic peptide derived from human HOOK1
Isotyp IgG
Reinigung Purified by Protein A.
Antigen
Andere Bezeichnung Hook1 (HOOK1 Antibody Abstract)
Hintergrund

Microtubules mediate the spatial organization of diverse membrane-trafficking systems. The HOOK proteins, HOOK1, HOOK2 and HOOK3, comprise a family of cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. HOOK1, a cytoskeletal linker protein, may play a role in endocytic membrane trafficking. It exists as a homodimer, most likely mediated through its central coiled-coil domain. HOOK1 interacts with VPS18 and is required for spermatid differentiation, in which it is most likely involved in the positioning of the manchette microtubules and the flagellum. HOOK1 localizes primarily to the cytoplasm and does not associate with the Golgi complex, unlike HOOK3, which participates in the organization of the cis-Golgi compartment.

Synonyms: A930033L17Rik, Abnormal spermatozoon head shape, azh, h-hook1, hHK1, HK1, HOOK 1, Hook homolog 1 Drosophila, Hook1, HOOK1_HUMAN, MGC10642, OTTHUMP00000010548, OTTMUSP00000008480, Protein Hook homolog 1, RP23-80B16.4.

Gen-ID 51361
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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