HIC1 Antikörper (Hypermethylated in Cancer 1) (Cy5)

Details for Product anti-HIC1 Antibody No. ABIN1704317
Antigen
  • zfHIC1
  • HIC1
  • ZBTB29
  • ZNF901
  • hic-1
  • AA408311
  • HIC-1
  • hypermethylated in cancer 1
  • HIC ZBTB transcriptional repressor 1
  • hic1
  • HIC1
  • Hic1
Reaktivität
Human, Maus, Ratte (Rattus)
87
29
27
9
7
7
5
3
2
2
1
Wirt
Kaninchen
49
28
11
Klonalität
Polyklonal
Konjugat
Dieser HIC1 Antikörper ist konjugiert mit Cy5
5
5
5
4
4
4
1
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
75
53
12
6
3
2
2
Optionen
Immunogen KLH conjugated synthetic peptide derived from human HIC1
Isotyp IgG
Reinigung Purified by Protein A.
Plasmids, Primers & others Plasmide, Primers & weitere HIC1 products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung Hic1 (HIC1 Antibody Abstract)
Hintergrund

Hypermethylated in cancer (HIC-1) was originally identified as a target of p53-induced gene expression. HIC-1 is deleted in the genetic disorder Miller-Dieker syndrome (MDS), and the expression of HIC-1 is also frequently suppressed in leukemia and various cancers due to the hypermethylation of specific DNA regions and the resulting transcriptional silencing. These and other studies indicate that HIC-1 acts as a putative tumor suppressor protein that mediates transcriptional repression. HIC-1 is ubiquitously expressed in adult tissues and its structure is defined by five zinc fingers and an N-terminal broad complex POZ (or BTB) domain. In several BTB/POZ containing proteins, including BCL-6 and the promyelocytic leukemia zinc-finger (PLZF) oncoprotein, this domain interacts with the SMRT/N-CoR-mSin3A HDAC complex and is directly involved in repressing and silencing gene transcription. When this domain is deleted, as with the oncogenic PLZF-RAR chimera of promyelocytic leukemias, this transcriptional repression is attenuated. Conversely, HIC-1 does not interact with components of the HDAC complex, suggesting that HIC-1-induced transcriptional repression is unassociated with the POZ/BTB domain.

Synonyms: Hic 1, Hic-1, Hic1, HIC1_HUMAN, Hypermethylated in cancer 1, Hypermethylated in cancer 1 protein, ZBTB29, Zinc finger and BTB domain-containing protein 29, ZNF901.

Gen-ID 3090
Pathways Positive Regulation of Response to DNA Damage Stimulus
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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