Cytochrome B5 Reductase 3 (CYB5R3) Antikörper (Cy5)

Details zu Produkt Nr. ABIN1704261
Antigen
  • B5R
  • DIA1
  • Dia1
  • Nadhcb5
  • RNNADHCB5
  • 0610016L08Rik
  • 2500002N19Rik
  • C85115
  • Dia-1
  • WU:AL591952.1-001
  • WU:AL591952.1-002
  • WU:AL591952.1-003
  • WU:Cyb5r3
  • fc32h03
  • zgc:77071
  • wu:fc32h03
  • dia1
  • CB5R
  • DDBDRAFT_0218707
  • DDBDRAFT_0266821
  • DDB_0218707
  • DDB_0266821
  • cytochrome b5 reductase 3
  • cytochrome b5 reductase 3 L homeolog
  • NADH-cytochrome b5 reductase
  • CYB5R3
  • Cyb5r3
  • cyb5r3
  • cyb5r3.L
  • CNM00240
  • Tb11.47.0018
  • cyb5r1
Reaktivität
Human, Maus, Ratte (Rattus)
121
60
38
9
7
5
2
1
1
1
Wirt
Kaninchen
95
47
14
Klonalität
Polyklonal
Konjugat
Cy5
13
9
8
4
4
3
3
3
3
3
3
2
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
119
83
54
20
18
12
10
7
5
4
4
4
2
2
2
Optionen
Immunogen KLH conjugated synthetic peptide derived from human CYB5R3
Isotyp IgG
Reinigung Purified by Protein A.
Antigen
Andere Bezeichnung Cyb5r3 (CYB5R3 Antibody Abstract)
Hintergrund

CYB5R3 is a 301 amino acid protein encoded by the human gene CYB5R3. CYB5R3 belongs to the flavoprotein pyridine nucleotide cytochrome reductase family and has two naturally occuring isoforms. Isoform 1 is anchored to the cytoplasmic side of the endoplasmic reticulum membrane and mitochondrion outer membrane, while isoform 2 is the soluble form found in erythrocytes. CYB5R3 is involved in the desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism and, in erythrocytes, methemoglobin reduction. A serine residue at position 117 seems to only be found in persons of African origin. The allele frequency is 0.23 in African Americans. It is not found in Caucasians, Asians, Indo-Aryans or Arabs. This difference seems to have no effect on the enzyme activity. Defects in CYB5R3 are the cause of hereditary methemoglobinemia (HM). There are three forms of this disease: type 1 (HM1), in which the enzyme is only deficient in erythrocytes with a mild cyanosis, type 2 (HM2), in which the enzyme is completely deficient, and type 3 (HM3), where the deficiency is seen in all blood cells. Type 2 is a severe form accompanied by mental retardation and neurological impairment.

Synonyms: B5R, Cyb5r3, Cytochrome b5 reductase 3, Cytochrome b5 reductase, DIA1, Diaphorase 1, Diaphorase-1, NADH cytochrome b5 reductase 3, NADH-cytochrome b5 reductase 3 membrane-bound form, NADH-cytochrome b5 reductase 3 soluble form, NB5R3_HUMAN, OTTHUMP00000028761, OTTHUMP00000198435, OTTHUMP00000198574, OTTHUMP00000198662, OTTHUMP00000198665.

Gen-ID 1727
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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