CSK Antikörper (C-Src tyrosine Kinase) (Cy5)

Details for Product anti-CSK Antibody No. ABIN1704258
Antigen
  • AW212630
  • C-terminal Src kinase
  • c-src tyrosine kinase
  • CSK, non-receptor tyrosine kinase
  • CSK
  • Csk
Reaktivität
Human, Maus, Ratte (Rattus)
190
116
101
9
8
5
4
2
2
2
1
1
1
Wirt
Kaninchen
153
31
9
Klonalität
Polyklonal
Konjugat
Dieser CSK Antikörper ist konjugiert mit Cy5
10
7
7
5
5
5
5
5
5
5
4
4
2
2
2
2
2
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
151
80
32
25
21
18
14
12
10
4
1
1
1
Optionen
Immunogen KLH conjugated synthetic peptide derived from human CSK
Isotyp IgG
Reinigung Purified by Protein A.
Plasmids, Primers & others Plasmide, Primers & weitere CSK products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung Csk (CSK Antibody Abstract)
Hintergrund

All members of the Src gene family of tyrosine kinases are characterized by a carboxy terminal domain tyrosine which is highly phosphorylated in the inactive form of the enzyme and phosphorylated to a much lesser extent when the enzyme is active. In the case of Src p60, Y527 is this tyrosine, however, a mutant form of c-Src in which Y527 is replaced by phenylalanine is transforming and displays 5- to 10-fold elevated kinase activity compared to its normal counterpart. Csk has been identified as a Src-related tyrosine kinase having both SH2 and SH3 domains and a catalytic domain but lacking sequences amino terminal to the SH3 domain as well as carboxy terminal regulatory sequences. Csk phosphorylates Src on Y527 and also downregulates Lyn, Fyn and Lck by tyrosine phosphorylation of carboxy terminal regulatory sites.

Synonyms: C SRC, C SRC kinase, C src Tyrosine Kinase, C-SRC kinase, c-src tyrosine kinase, Csk A, CSK, CSK_HUMAN, CYTOPLASMIC TYROSINE KINASE, EC 2.7.10.2, MGC112926, MGC117393, MGC154049, P60 Src, Protein tyrosine kinase CYL, Protein-tyrosine kinase CYL, Proto oncogene tyrosine protein kinase, Tyrosine protein kinase CSK, Tyrosine-protein kinase CSK, zgc:154049.

Gen-ID 1445
Pathways T-Zell Rezeptor Signalweg, EGFR Signaling Pathway, Cell-Cell Junction Organization, CXCR4-mediated Signaling Events
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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