The bromodomain-containing proteins include BRD2, BRD3, BRD4 and BRDT. BRD2 (RING3 protein) is a mitogen-activated nuclear protein whose gene is located in the human MHC II region, suggesting its relation to HLA-associated diseases. The gene encoding BRD3 (RING3-like protein) contains two bromodomains and maps to chromosome 9q34. BRD4 (HUNK1 protein) is a nuclear protein involved in the regulation of chromosomal dynamics during mitosis. The testis-specific bromodomain protein BRDT contains a PEST sequence, indicating that it undergoes rapid intracellular degradation. The bromodomain-containing proteins are ubiquitously expressed.
Synonyms: BRD 2, Brd2, BRD2_HUMAN, Bromodomain containing 2, BROMODOMAIN CONTAINING PROTEIN2, Bromodomain-containing protein 2, D6S113E, DKFZp686N0336, female sterile homeotic related gene 1, FLJ31942, FSH, FSRG1, KIAA9001, NAT, O27.1.1, Really interesting new gene 3 protein, Ring3, RING3 PROTEIN, RNF3.