ARFGEF1 Antikörper (ADP-Ribosylation Factor Guanine Nucleotide-Exchange Factor 1(brefeldin A-Inhibited)) (Cy5)

Details for Product anti-ARFGEF1 Antibody No. ABIN1704235
Antigen
  • ARFGEF1
  • ARFGEP1
  • BIG1
  • P200
  • D130059B05Rik
  • D730028O18Rik
  • RGD1560793
  • ADP ribosylation factor guanine nucleotide exchange factor 1
  • brefeldin A-inhibited guanine nucleotide-exchange protein 1
  • ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)
  • ARFGEF1
  • CpipJ_CPIJ004831
  • Arfgef1
Reaktivität
Human, Maus, Ratte (Rattus)
26
25
17
4
4
3
2
2
2
2
1
1
1
1
Wirt
Kaninchen
25
1
Klonalität
Polyklonal
Konjugat
Dieser ARFGEF1 Antikörper ist konjugiert mit Cy5
2
2
2
2
2
2
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
12
7
5
2
2
1
1
Optionen
Immunogen KLH conjugated synthetic peptide derived from human BIG1/ARFGEF1
Isotyp IgG
Reinigung Purified by Protein A.
Plasmids, Primers & others Plasmide, Primers & weitere ARFGEF1 products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung Big1/Arfgef1 (ARFGEF1 Antibody Abstract)
Hintergrund

Guanine nucleotide-exchange proteins (GEPs) accelerate replacement of bound GDP with GTP and thereby activate ADP-ribosylation factors (ARFs), a family of guanine nucleotide-binding proteins that play an important role in intracellular vesicular trafficking. GEPs comprise two major families, large GEPs that are inhibited by brefeldin A (BFA), a protein that effects Golgi structure and a group of smaller GEPs that are insenstive to BFA. Two genes for GEPs found on human chromosomes 8 and 20 encode BFA sensitive GEPs designated BIG1 and BIG2. Both GEPS contain a sec7 domain that is responsible for their brefeldin inhibition and also their catalytic activity. In vivo, BIG1 and BIG2 exist in macromolecular complexes that move between the Golgi membranes and cytosol. BIG2 associates with PKA regulatory subunits, implying that BIG2 may act as an A kinase-anchoring protein (AKAP) that could coordinate the cAMP and ARF regulatory pathways.

Synonyms: ADPribosylation factor guanine nucleotide exchange factor 1brefeldin A inhibited, ARFGEF1, ARFGEP1, Brefeldin A inhibited GEP 1, Brefeldin A inhibited guanine nucleotide exchange protein 1, p200 ARF GEP1, p200 ARF guanine nucleotide exchange factor, BIG1_HUMAN.

Gen-ID 10565
Pathways Regulation of Actin Filament Polymerization, Regulation of Carbohydrate Metabolic Process
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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