Dynamin 1 Antikörper (DNM1) (Cy5)

Details for Product anti-DNM1 Antibody No. ABIN1704211
Target
Reaktivität
Human, Maus, Ratte
103
84
82
9
9
6
2
2
2
2
1
Wirt
Kaninchen
90
13
6
Klonalität
Polyklonal
Konjugat
Dieser Dynamin 1 Antikörper ist konjugiert mit Cy5
6
5
4
4
3
3
3
3
3
3
3
3
3
2
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
67
38
28
27
18
7
6
6
4
4
2
2
1
1
Optionen
Immunogen KLH conjugated synthetic peptide derived from human Dynamin 1
Isotyp IgG
Reinigung Purified by Protein A.
Target
Andere Bezeichnung Dynamin 1 (DNM1 Antibody Abstract)
Hintergrund

Dynamin I is a GTPase enzyme required for the retrieval of synaptic vesicles after exocytosis and functions in endocytosis by stimulating assembly of invaginating synaptic vesicles (1). Dynamin I is phosphorylated in nerve terminals exclusively in the cytosolic compartment and in vitro by protein kinase C (PKC) (2â€"5). The phosphorylation site in PKC-phosphorylated Dynamin I is a single site at Serine 795, which is located near a binding site for the SH3 domain of p85, the regulatory subunit of phosphatidylinositol 3-kinase (2â€"5). Dephosphorylation is required for synaptic vesicle retrieval, suggesting that phosphorylation affects the subcellular localization of Dynamin I (5). Mouse, rat and human Dynamin I are phosphorylated on serine residues, including Ser 778, by Cdk5, regulating PACSIN1 recruitment and enabling synaptic vesicle endocytosis.

Synonyms: B dynamin, D100, DNM 1, DNM, DNM1, DYN1_HUMAN, Dynamin, Dynamin-1, Dynamin1.

Gen-ID 1759
Pathways Toll-Like Receptors Cascades, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months