IFT122 is a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This cytoplasmic protein contains seven WD repeats and an AF-2 domain which function by recruiting coregulatory molecules and in transcriptional activation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Synonyms: CED, 122_HUMAN, T122, Intraflagellar transport 122 homolog Chlamydomonas, Intraflagellar transport protein 122 homolog, SPG, WD repeat domain 10, WD repeat-containing protein 10, WD repeat-containing protein 140, WDR10, WDR10p, WDR140.