TAZ Antikörper (AA 1-100) (Cy3)
-
- Target Alle TAZ Antikörper anzeigen
- TAZ (Tafazzin (TAZ))
-
Bindungsspezifität
- AA 1-100
-
Reaktivität
- Human, Maus, Ratte
-
Wirt
- Kaninchen
-
Klonalität
- Polyklonal
-
Konjugat
- Dieser TAZ Antikörper ist konjugiert mit Cy3
-
Applikation
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Flow Cytometry (FACS)
- Kreuzreaktivität
- Human, Maus, Ratte
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human TAZ
- Isotyp
- IgG
- Top Product
- Discover our top product TAZ Primärantikörper
-
-
- Applikationshinweise
-
FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Haltbarkeit
- 12 months
-
- Target
- TAZ (Tafazzin (TAZ))
- Andere Bezeichnung
- TAZ (TAZ Produkte)
- Synonyme
- wu:fb39f12 antikoerper, zgc:91803 antikoerper, MGC54019 antikoerper, TAZ antikoerper, taz antikoerper, GB11956 antikoerper, Afu2g13960 antikoerper, BTHS antikoerper, CMD3A antikoerper, EFE antikoerper, EFE2 antikoerper, G4.5 antikoerper, LVNCX antikoerper, Taz1 antikoerper, 5031411C02Rik antikoerper, 9130012G04Rik antikoerper, AW107266 antikoerper, AW552613 antikoerper, tafazzin antikoerper, tafazzin L homeolog antikoerper, tafazzin homolog antikoerper, TAZ antikoerper, taz antikoerper, taz.L antikoerper, LOC550948 antikoerper, AFUA_2G13960 antikoerper, AOR_1_318014 antikoerper, Tsp_06712 antikoerper, Taz antikoerper
- Hintergrund
-
Synonyms: TAZ, WW domain-containing transcription regulator protein 1, Transcriptional coactivator with PDZ-binding motif, WWTR1
Background: Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.
- Gen-ID
- 25937
- UniProt
- Q9GZV5
-