GRB14 Antikörper (AA 221-320) (Cy3)

Produktnummer ABIN1702143

Dieses Anti-GRB14-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von GRB14 in IF (cc) und IF (p). Geeignet für Human.

Kurzübersicht für GRB14 Antikörper (AA 221-320) (Cy3) (ABIN1702143)

Target: GRB14 (Growth Factor Receptor-Bound Protein 14 (GRB14))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GRB14 Antikörper ist konjugiert mit Cy3

Applikation: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-GRB14 Antikörper (Cy3)

Bindungsspezifität: AA 221-320

Spezifität: This antibody may also detect the similar protein GRB10 due to an 83 % sequence similarity in the immunogen sequence.

Kreuzreaktivität: Human

Homologie: Mouse,Rat,Dog,Cow,Sheep,Horse,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GRB 14

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu GRB14

Target: GRB14 (Growth Factor Receptor-Bound Protein 14 (GRB14))

Andere Bezeichnung: GRB 14

Hintergrund:

Synonyms: Growth factor receptor-bound protein 14, GRB14 adapter protein, GRB14

Background: Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.

Gen-ID: 2888

UniProt: Q14449