CSK Antikörper (pSer364) (Biotin)

Produktnummer ABIN1700829

Dieses Anti-CSK-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CSK in WB, ELISA, IHC (p) und IHC (fro). Geeignet für Human und Ratte.

Kurzübersicht für CSK Antikörper (pSer364) (Biotin) (ABIN1700829)

Target: CSK (C-Src tyrosine Kinase (CSK))

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CSK Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-CSK Antikörper (Biotin)

Bindungsspezifität: pSer364

Kreuzreaktivität: Human, Ratte

Homologie: Mouse,Cow,Sheep,Pig,Horse,Chicken

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human CSK around the phosphorylation site of Ser364

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu CSK

Target: CSK (C-Src tyrosine Kinase (CSK))

Andere Bezeichnung: CSK

Hintergrund:

Synonyms: CSKphospho S364, p-CSKphospho S364, C SRC, C SRC kinase, C src Tyrosine Kinase, C-SRC kinase, c-src tyrosine kinase, Csk A, CSK, CSK_HUMAN, CYTOPLASMIC TYROSINE KINASE, EC 2.7.10.2, MGC112926, MGC117393, MGC154049, P60 Src, Protein tyrosine kinase CYL, Protein-tyrosine kinase CYL, Proto oncogene tyrosine protein kinase, Tyrosine protein kinase CSK, Tyrosine-protein kinase CSK, zgc:154049.

Background: All members of the Src gene family of tyrosine kinases are characterized by a carboxy terminal domain tyrosine which is highly phosphorylated in the inactive form of the enzyme and phosphorylated to a much lesser extent when the enzyme is active. In the case of Src p60, Y527 is this tyrosine, however, a mutant form of c-Src in which Y527 is replaced by phenylalanine is transforming and displays 5- to 10-fold elevated kinase activity compared to its normal counterpart. Csk has been identified as a Src-related tyrosine kinase having both SH2 and SH3 domains and a catalytic domain but lacking sequences amino terminal to the SH3 domain as well as carboxy terminal regulatory sequences. Csk phosphorylates Src on Y527 and also downregulates Lyn, Fyn and Lck by tyrosine phosphorylation of carboxy terminal regulatory sites.

Gen-ID: 1445

Pathways: T-Zell Rezeptor Signalweg, EGFR Signaling Pathway, Cell-Cell Junction Organization, CXCR4-mediated Signaling Events