CHTOP Antikörper (AA 31-130) (Biotin)

Produktnummer ABIN1700622

Dieses Anti-CHTOP-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CHTOP in ELISA, IHC (fro) und IHC (p). Geeignet für Human.

Kurzübersicht für CHTOP Antikörper (AA 31-130) (Biotin) (ABIN1700622)

Target: CHTOP (Chromatin Target of PRMT1 (CHTOP))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CHTOP Antikörper ist konjugiert mit Biotin

Applikation: ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-CHTOP Antikörper (Biotin)

Bindungsspezifität: AA 31-130

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Chicken

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human C1orf77

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu CHTOP

Target: CHTOP (Chromatin Target of PRMT1 (CHTOP))

Andere Bezeichnung: C1orf77

Hintergrund:

Synonyms: Chromatin target of PRMT1 protein, Chromosome 1 open reading frame 77, CHTOP, CHTOP_HUMAN, DKFZp547E1010, FOP, Friend of PRMT1 protein, MGC131924, MGC86949, OTTHUMP00000035122, OTTHUMP00000035123, Pp7704, RP1 178F15.2, Small arginine- and glycine-rich protein, Small protein rich in arginine and glycine, SRAG.

Background: C1orf77, also known as Friend of PRMT1 protein, is a 248 amino acid protein that plays an essential role in the ligand-dependent activation of estrogen receptor target genes. C1orf77 is tightly associated with chromatin and is modified by both asymmetric and symmetric arginine methylation. Depletion of C1orf77 results in almost complete block of estradiol-induced promter occupancy by the estrogen receptor. Also, complete knockdown of C1orf77 mRNA in adult erythroid progenitors stongly induces fetal hemoglobin, suggesting that C1orf77 is a critical modulator of _-globin gene expression. There are two isoforms of C1orf77 that are produced as a result of alternative splicing events. The gene encoding C1orf77 maps to human chromosome 1, the largest human chromosome spanning about 260 million base pairs and making up 8 % of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1.

Gen-ID: 26097