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Cytohesin 2 Antikörper (AA 21-120) (Biotin)

CYTH2 Reaktivität: Human, Ratte WB, ELISA, IHC (p), IHC (fro) Wirt: Kaninchen Polyclonal Biotin
Produktnummer ABIN1700585
  • Target Alle Cytohesin 2 (CYTH2) Antikörper anzeigen
    Cytohesin 2 (CYTH2)
    Bindungsspezifität
    • 14
    • 9
    • 8
    • 7
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 21-120
    Reaktivität
    • 31
    • 19
    • 18
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Ratte
    Wirt
    • 39
    • 3
    • 1
    Kaninchen
    Klonalität
    • 41
    • 2
    Polyklonal
    Konjugat
    • 20
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Cytohesin 2 Antikörper ist konjugiert mit Biotin
    Applikation
    • 42
    • 19
    • 13
    • 13
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Kreuzreaktivität
    Human, Ratte
    Homologie
    Mouse,Dog,Sheep,Pig,Horse,Chicken
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Cytohesin 2
    Isotyp
    IgG
    Top Product
    Discover our top product CYTH2 Primärantikörper
  • Applikationshinweise
    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C for 12 months.
    Haltbarkeit
    12 months
  • Target
    Cytohesin 2 (CYTH2)
    Andere Bezeichnung
    Cytohesin 2 (CYTH2 Produkte)
    Synonyme
    ARNO antikoerper, CTS18 antikoerper, CTS18.1 antikoerper, PSCD2 antikoerper, PSCD2L antikoerper, SEC7L antikoerper, Sec7p-L antikoerper, Sec7p-like antikoerper, CLM2 antikoerper, Pscd2 antikoerper, Arno antikoerper, Sec7 antikoerper, Sec7B antikoerper, pscd2 antikoerper, MGC84366 antikoerper, CYTH2 antikoerper, cyth2 antikoerper, cytohesin 2 antikoerper, cytohesin-2 antikoerper, cytohesin 2 L homeolog antikoerper, si:dkey-283b15.4 antikoerper, CYTH2 antikoerper, PTRG_08834 antikoerper, Cyth2 antikoerper, cyth2.L antikoerper, cyth2 antikoerper, si:dkey-283b15.4 antikoerper
    Hintergrund

    Synonyms: ARF exchange factor, ARF nucleotide binding site opener, Arno, ARNO protein, CLM2, CTS18, CTS18.1, Cyth2, Cytohesin 2, MGC137537, MGC80440, PH, SEC7 and coiled-coil domain-containing protein 2, Pleckstrin homology Sec7 and coiled coil domains 2, Pleckstrin homology Sec7 and coiled coil domains protein 2, PSCD2, PSCD2L, PSCD2L, formerly, Sec7, SEC7 homolog B, Sec7B, SEC7L, Sec7p L, Sec7p-like, Sec7pL, CYH2_HUMAN.

    Background: The ADP-ribosylation factor (Arf) family comprises a group of structurally and functionally conserved 21 kDa proteins, which are members of the Ras superfamily of regulatory GTP-binding proteins. Arf is involved in intracellular protein traffic to and within the Golgi complex. Arf has a number of disparate activities including maintenance of organelle integrity, assembly of coat proteins, as a co-factor for cholera toxin and as an activator of phospholipase D. Like other small GTPases, Arf is found to be active when bound to GTP and inactive when bound to GDP. Arf?s activation is dependent upon guanine nucleotide exchange factors (GEFs) which increase the rate of exchange of bound GDP with GTP. All GEFs have a highly conserved Sec7 domain. GEF activity lies in the Sec7 domain and this activity has been shown to be inhibited by the fungal metabolite brefeldin-A (BFA). A small group of GEFs which are insensitive to brefeldin-A (BFA) include cytohesin-1 (B2-1), cytohesin-2 (ARNO), cytohesin-3 (ARNO3), and cytohesin-4. All cytohesins function in the cell periphery and contain a pleckstrin homology (PH) domain. The PH domain has been shown to interact with phosphatidylinositol 3,4,5-triphosphate and is believed to promote membrane targeting of the cytohesins. Recruitment of the cytohesins to the membranes can occur in response to tyrosine kinase receptor activation. This response appears to require the activation of phosphatidylinositol 3-kinase (PI 3-kinase).

    Gen-ID
    9266
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