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NOSTRIN Antikörper (AA 301-400) (Biotin)

NOSTRIN Reaktivität: Human ELISA, IHC (p), IHC (fro) Wirt: Kaninchen Polyclonal Biotin
Produktnummer ABIN1700370
  • Target Alle NOSTRIN Antikörper anzeigen
    NOSTRIN (Nitric Oxide Synthase Trafficker (NOSTRIN))
    Bindungsspezifität
    • 14
    • 7
    • 6
    • 5
    • 5
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 301-400
    Reaktivität
    • 39
    • 13
    • 3
    Human
    Wirt
    • 41
    • 1
    Kaninchen
    Klonalität
    • 41
    • 1
    Polyklonal
    Konjugat
    • 15
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser NOSTRIN Antikörper ist konjugiert mit Biotin
    Applikation
    • 22
    • 22
    • 13
    • 13
    • 6
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Homologie
    Human,Mouse,Rat,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human NOSTRIN
    Isotyp
    IgG
    Top Product
    Discover our top product NOSTRIN Primärantikörper
  • Applikationshinweise
    IHC-P 1:200-400
    IHC-F 1:100-500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C for 12 months.
    Haltbarkeit
    12 months
  • Target
    NOSTRIN (Nitric Oxide Synthase Trafficker (NOSTRIN))
    Andere Bezeichnung
    NOSTRIN (NOSTRIN Produkte)
    Synonyme
    NOSTRIN antikoerper, MGC171848 antikoerper, Daip2 antikoerper, mDaIP2 antikoerper, DaIP2 antikoerper, nitric oxide synthase trafficking antikoerper, nitric oxide synthase trafficking L homeolog antikoerper, nitric oxide synthase trafficker antikoerper, NOSTRIN antikoerper, nostrin antikoerper, nostrin.L antikoerper, Nostrin antikoerper
    Hintergrund

    Synonyms: BM247, BM247 homolog, DaIP2, eNOS-trafficking inducer, mDaIP2, MGC20702, Nitric oxide synthase traffic inducer, Nitric oxide synthase trafficker, NOSTN_HUMAN, Nostrin, RP23-431D4.2

    Background: NOSTRIN (nitric oxide synthase trafficker isoform 1), also known as endothelial nitric oxide synthase traffic inducer, is a member of the Pombe Cdc15 homology (PCH) family of proteins. NOSTRIN is expressed in the vascular endothelial cells of highly vascularized tissues such as placenta, lung, kidney and heart. It consists of an N-terminal Cdc15 domain with an FCH (Fes/CIP homology) region, two coiled coil domains and a C-terminal SH3 domain. NOSTRIN typically exists as a trimer. It functions as an adaptor protein binding to caveolin-1 via an internal domain and NOS3 via its SH3 domain, forming a ternary complex which facilitates caveolar transport of NOS3. The NOS3 protein is responsible for the production of nitric oxide (NO), a potent mediator in various biological processes. The translocation of NOS3 from the plasma membrane to intracellular vesicle-like structures diminishes NO production. NOSTRIN also interacts with Dynamin and N-WASP via its SH3 domain.

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