Clca3 Antikörper (AbBy Fluor® 555)

Produktnummer ABIN1698002

Der Kaninchen Polyklonal Anti-Clca3-Antikörper wurde für WB, IF (cc) und IF (p) validiert. Er ist geeignet, Clca3 in Proben von Maus und Ratte zu detektieren.

Kurzübersicht für Clca3 Antikörper (AbBy Fluor® 555) (ABIN1698002)

Target: Clca3 (CLCA3) (Epithelial Chloride Channel Protein (CLCA3))

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Clca3 Antikörper ist konjugiert mit AbBy Fluor® 555

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-Clca3 Antikörper (AbBy Fluor® 555)

Homologie: Mouse,Rat,Dog

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from mouse CLCA3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu Clca3

Target: Clca3 (CLCA3) (Epithelial Chloride Channel Protein (CLCA3))

Andere Bezeichnung: Clca3

Hintergrund:

Synonyms: Calcium activated chloride channel 3, Calcium-activated chloride channel regulator family member 3, Chloride channel accessory 3 pseudogene, chloride channel calcium activated 3, Chloride channel calcium activated family member 3, Clca1, Clca2, CLCA3P, Gob 5, Gob-5, Gob5, hCLCA3, mCLCA3, MGC143984, MGC143985.

Background: The calcium-activated chloride channel (CLCA) protein family, which includes the human homologs CLCA1 and CLCA2, display distinct tissue distribution patterns. CLCA1 is expressed as a precursor protein that is processed into two cell surface associated subunits and a group of proteins. CLCA1 is upregulated by interleukin-9 and regulates the expression of mucins. CLCA1 may provide a therapeutic target to control mucus overproduction in airway disease patients with cystic fibrosis. CLCA2 expression is downregulated in breast cancer, therefore CLCA2 is thought to act as a tumor suppressor in normal cells. CLCA3 (known as Clca3 in mouse) is a structurally divergent member of the CLCA family that does not function as a channel protein. CLCA4 is a CLCA member that is expressed in human rectal mucosa, CLCA5 shows strong expression in eye and spleen, and CLCA6 is primarily expressed in intestine and stomach.