CYB5R3 Antikörper (AbBy Fluor® 555)

Produktnummer ABIN1697013

Dieses Anti-CYB5R3-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CYB5R3 in WB. Geeignet für Human, Maus und Ratte.

Kurzübersicht für CYB5R3 Antikörper (AbBy Fluor® 555) (ABIN1697013)

Target: CYB5R3 (Cytochrome B5 Reductase 3 (CYB5R3))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CYB5R3 Antikörper ist konjugiert mit AbBy Fluor® 555

Applikation: Western Blotting (WB)

Produktdetails anti-CYB5R3 Antikörper (AbBy Fluor® 555)

Kreuzreaktivität: Maus

Homologie: Human,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CYB5R3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu CYB5R3

Target: CYB5R3 (Cytochrome B5 Reductase 3 (CYB5R3))

Andere Bezeichnung: Cyb5r3

Hintergrund:

Synonyms: B5R, Cyb5r3, Cytochrome b5 reductase 3, Cytochrome b5 reductase, DIA1, Diaphorase 1, Diaphorase-1, NADH cytochrome b5 reductase 3, NADH-cytochrome b5 reductase 3 membrane-bound form, NADH-cytochrome b5 reductase 3 soluble form, NB5R3_HUMAN, OTTHUMP00000028761, OTTHUMP00000198435, OTTHUMP00000198574, OTTHUMP00000198662, OTTHUMP00000198665.

Background: CYB5R3 is a 301 amino acid protein encoded by the human gene CYB5R3. CYB5R3 belongs to the flavoprotein pyridine nucleotide cytochrome reductase family and has two naturally occuring isoforms. Isoform 1 is anchored to the cytoplasmic side of the endoplasmic reticulum membrane and mitochondrion outer membrane, while isoform 2 is the soluble form found in erythrocytes. CYB5R3 is involved in the desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism and, in erythrocytes, methemoglobin reduction. A serine residue at position 117 seems to only be found in persons of African origin. The allele frequency is 0.23 in African Americans. It is not found in Caucasians, Asians, Indo-Aryans or Arabs. This difference seems to have no effect on the enzyme activity. Defects in CYB5R3 are the cause of hereditary methemoglobinemia (HM). There are three forms of this disease: type 1 (HM1), in which the enzyme is only deficient in erythrocytes with a mild cyanosis, type 2 (HM2), in which the enzyme is completely deficient, and type 3 (HM3), where the deficiency is seen in all blood cells. Type 2 is a severe form accompanied by mental retardation and neurological impairment.

Gen-ID: 1727

Pathways: SARS-CoV-2 Protein Interaktom