KAT5 Antikörper (AA 51-150) (AbBy Fluor® 555)

Produktnummer ABIN1696728

Dieses Anti-KAT5-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von KAT5 in WB, IF (cc) und IF (p). Geeignet für Maus und Ratte.

Kurzübersicht für KAT5 Antikörper (AA 51-150) (AbBy Fluor® 555) (ABIN1696728)

Target: KAT5 (K(lysine) Acetyltransferase 5 (KAT5))

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KAT5 Antikörper ist konjugiert mit AbBy Fluor® 555

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-KAT5 Antikörper (AbBy Fluor® 555)

Bindungsspezifität: AA 51-150

Kreuzreaktivität: Maus, Ratte

Homologie: Human,Dog,Sheep,Pig,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human KAT5 / Tip60

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu KAT5

Target: KAT5 (K(lysine) Acetyltransferase 5 (KAT5))

Andere Bezeichnung: Kat5 / Tip60

Hintergrund:

Synonyms: 60 kDa Tat interactive protein, 60 kDa Tat-interactive protein, cPLA2 interacting protein, cPLA2-interacting protein, cPLA2, cPLA2 interacting protein, ESA1, Histone acetyltransferase HTATIP, Histone acetyltransferase KAT5, HIV 1 Tat interactive protein, HIV 1 Tat interactive protein, 60 kDa, HIV-1 Tat interactive protein, HTATIP, HTATIP1, Klysine acetyltransferase 5, K-acetyltransferase 5, KAT5, KAT5_HUMAN, Lysine acetyltransferase 5, PLIP, Tat interacting protein, 60 kDa, TIP, Tip60.

Background: MOZ (monocytic leukemia zinc finger protein) is a chromatin-associated histone acetyltransferase (HAT) that regulates chromatin remodeling and transcription. The MOZ gene was initially isolated as a consequence of two variant translocations that were identified in a distinct subtype of acute myeloid leukemias and resulted in the formation of MOZ fusion proteins. These fusions involve the HAT domain of MOZ with the activation domain of either transcriptional coactivator protein TIF2/GRIP1 or CBP, and lead to enhanced transcriptional activation by a mechanism involving aberrant histone acetylation. Additional MOZ related proteins, including MORF (MOZ related factor) and TIP60 (TAT interacting proteins 60), share significant similarities with MOZ including the putuative HAT domain. MORF also contains a strong transcriptional repression domain at its N terminus and a highly potent activation domain at the C terminus, suggesting that MORF has both HAT activity and contributes to the regulation of transcriptional activation. TIP60 was originally identified as a coactivator for the HIV TAT protein and also functions as a nuclear hormone receptor coactivator that enhances ligand dependent steroid receptor-mediated transactivation involving the androgen, estrogen and progesterone receptors.

UniProt: Q92993

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway