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GAB4 Antikörper (AA 101-200) (Alexa Fluor 350)

GAB4 Reaktivität: Human IF (cc), IF (p) Wirt: Kaninchen Polyclonal Alexa Fluor 350
Produktnummer ABIN1694018
$438.15
Zzgl. Versandkosten $45.00
100 μL
Lieferung in 11 bis 16 Werktagen
  • Target See all GAB4 products
    GAB4 (GRB2-Associated Binding Protein Family, Member 4 (GAB4))
    Bindungsspezifität
    • 14
    • 9
    • 9
    • 8
    • 1
    • 1
    • 1
    AA 101-200
    Reaktivität
    Human
    Wirt
    • 35
    Kaninchen
    Klonalität
    • 35
    Polyklonal
    Konjugat
    • 10
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser GAB4 Antikörper ist konjugiert mit Alexa Fluor 350
    Applikation
    • 22
    • 17
    • 16
    • 12
    • 12
    • 3
    • 3
    • 2
    • 1
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Homologie
    Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human GAB4
    Isotyp
    IgG
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C/-80 °C
    Informationen zur Lagerung
    Store at -20°C, for long storage, store at -80°C. Avoid multiple freeze-thaw cycles
    Haltbarkeit
    12 months
  • Target
    GAB4 (GRB2-Associated Binding Protein Family, Member 4 (GAB4))
    Andere Bezeichnung
    GAB4 (GAB4 Produkte)
    Synonyme
    GRB2 associated binding protein family member 4, GAB4
    Hintergrund

    The Gab family of adaptor proteins function as molecular scaffolds that mediate protein recruit-ment to RTKs. Cytokine/growth factor triggering of protein tyrosine kinase receptors (RTKs) initiates signaling cascades that progress to the nucleus where signals for activation, proliferation and differentiation occur. This scaffolding mechanism represents a critical link in cytokine/growth factor signaling routes. Gab 1-4 contain Pleckstrin homology and potential binding sites for SH2 and SH3 domain-containing proteins. The recruitment of signaling partners to Gab family members is phosphorylation-dependent. Insulin receptor and EGF receptor signaling are among the cascades that rely on Gab family members to elicit a nuclear response to an extracellular stimulus. Gab 4 (GRB2-associated-binding protein 4), also designated GRB2-associated-binding protein 2-like (Gab 2-like), is a 574 amino acid protein that shares 62 % sequence similarity with Gab 2 and contains one Pleckstrin homology domain.

    Subcellular location: Cytoplasm

    Synonyms: GAB2-like, GAB4, GAB4_HUMAN, GRB2 associated binder 2 like protein, GRB2 associated binding protein family member 4, GRB2-associated binder 2-like, GRB2-associated binder 4, GRB2-associated-binding protein 2-like, GRB2-associated-binding protein 4, Growth factor receptor bound protein 2-associated protein 4.

    Gen-ID
    128954
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