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EYA4 Antikörper (AA 301-400) (Alexa Fluor 350)

EYA4 Reaktivität: Human IF (cc), IF (p) Wirt: Kaninchen Polyclonal Alexa Fluor 350
Produktnummer ABIN1693979
$438.15
Zzgl. Versandkosten $45.00
100 μL
Lieferung in 11 bis 16 Werktagen
  • Target Alle EYA4 Antikörper anzeigen
    EYA4 (Eyes Absent Homolog 4 (EYA4))
    Bindungsspezifität
    • 16
    • 14
    • 9
    • 9
    • 5
    • 1
    • 1
    • 1
    AA 301-400
    Reaktivität
    • 50
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 43
    • 7
    Kaninchen
    Klonalität
    • 50
    Polyklonal
    Konjugat
    • 15
    • 6
    • 5
    • 5
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser EYA4 Antikörper ist konjugiert mit Alexa Fluor 350
    Applikation
    • 28
    • 24
    • 19
    • 17
    • 12
    • 12
    • 7
    • 3
    • 3
    • 2
    • 1
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Homologie
    Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human EYA4
    Isotyp
    IgG
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C/-80 °C
    Informationen zur Lagerung
    Store at -20°C, for long storage, store at -80°C. Avoid multiple freeze-thaw cycles
    Haltbarkeit
    12 months
  • Target
    EYA4 (Eyes Absent Homolog 4 (EYA4))
    Andere Bezeichnung
    EYA4 (EYA4 Produkte)
    Synonyme
    B130023L16Rik, CMD1J, DFNA10, EYA transcriptional coactivator and phosphatase 4, Eya4, EYA4
    Hintergrund

    A gene of chromosome 6q23 encodes the 640 amino acid protein, EYA4 (eyes absent) (1). EYA is one of four members of the eyes absent family (1). A 271 amino acid domain at the carboxyl terminal is highly conserved amongst the members of the eyes absent family (1). EYA4 is expressed in the craniofacial mesenchyme, the dermamyotome, and the limb (1). The conserved region in other EYA proteins interacts with SIX, DACH, and G-proteins, which regulate transcription in early embryonic development (1,2,3,4). SIX translocates EYA1-3 to the nucleus, and G-proteins can stop this interaction (3,4). Premature stop codon mutations in EYA4 cause postlingual, progressive autosomal dominant hearing loss in humans (2). This shows that EYA4 is also vital to the mature organ of Corti (2). EYA4 may cause oculo-dento-digital syndrome, based on its expression pattern and map postion (1).

    Subcellular location: Cytoplasm, Nucleus

    Synonyms: CMD1J, Deafness, autosomal dominant 10, DFNA 10, DFNA10, dJ78N10.1 eyes absent Drosophila homolog 4, dJ78N10.1 eyes absent, EYA 4, eya4, EYA4_HUMAN, Eyes absent 4, Eyes absent homolog 4 Drosophila, Eyes absent homolog 4, HGNC:3522, OTTHUMP00000040267.

    Gen-ID
    2070
    Pathways
    Sensory Perception of Sound
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