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FRAT1 Antikörper (AA 161-260) (Alexa Fluor 350)

FRAT1 Reaktivität: Human IF (cc), IF (p) Wirt: Kaninchen Polyclonal Alexa Fluor 350
Produktnummer ABIN1693768
$438.15
Zzgl. Versandkosten $45.00
100 μL
Lieferung in 11 bis 16 Werktagen
  • Target Alle FRAT1 Antikörper anzeigen
    FRAT1 (Frequently Rearranged in Advanced T-Cell Lymphomas (FRAT1))
    Bindungsspezifität
    • 14
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 161-260
    Reaktivität
    • 28
    • 1
    Human
    Wirt
    • 27
    • 1
    Kaninchen
    Klonalität
    • 27
    • 1
    Polyklonal
    Konjugat
    • 13
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser FRAT1 Antikörper ist konjugiert mit Alexa Fluor 350
    Applikation
    • 15
    • 12
    • 12
    • 8
    • 6
    • 5
    • 3
    • 2
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Homologie
    Human,Mouse,Rat,Dog,Cow
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human FRAT1
    Isotyp
    IgG
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C/-80 °C
    Informationen zur Lagerung
    Store at -20°C, for long storage, store at -80°C. Avoid multiple freeze-thaw cycles
    Haltbarkeit
    12 months
  • Target
    FRAT1 (Frequently Rearranged in Advanced T-Cell Lymphomas (FRAT1))
    Andere Bezeichnung
    FRAT1 (FRAT1 Produkte)
    Synonyme
    FRAT1, frat1, AW060382, gbp, FRAT1, WNT signaling pathway regulator, GSK-3 binding protein FRAT1, frequently rearranged in advanced T cell lymphomas, frequently rearranged in advanced T-cell lymphomas, frequently rearranged in advanced T-cell lymphomas 1 S homeolog, FRAT1, frat1, Frat1, frat1.S
    Hintergrund

    FRAT1 and FRAT2 were originally characterized as proteins frequently rearranged in advanced T cell lymphoma, and they have since been identified as proto-oncogenes involved in tumorigenesis. These proteins share significant homology with the Xenopus glycogen synthase kinase-3 (xGSK-3) binding protein, which is designated GBP and is essential for the formation of the dorsal-ventral axis during embryonic development. Establishment of these embryonic axes is mediated by the Wnt intracellular signaling pathway. Wnt signaling is regulated in part by the activity of GSK-3, which phosphorylates and thereby facilitates the degradation of ?catenin. GBP binds to GSK-3 and inhibits this phosphorylation, resulting in the accumulation of ?catenin and the subsequent transcription of Wnt target genes. Like GBP, FRAT2 has been shown to bind xGSK-3, suggesting that FRAT1 and FRAT2 may be GSK-3 regulatory proteins.

    Subcellular location: Cytoplasm

    Synonyms: FRAT 1, frequently rearranged in advanced T cell lymphomas, Frequently rearranged in advanced T-cell lymphomas, GSK 3 binding protein FRAT1, proto oncogene FRAT1, FRAT1_HUMAN.

    Gen-ID
    10023
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